A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)

PHASE3RecruitingINTERVENTIONAL
Enrollment

470

Participants

Timeline

Start Date

April 29, 2024

Primary Completion Date

April 30, 2028

Study Completion Date

December 31, 2028

Conditions
Advanced or Metastatic NRAS-mutant Melanoma
Interventions
DRUG

Naporafenib

Naporafenib (ERAS-254) is an experimental Pan-Raf inhibitor

DRUG

Dacarbazine

Dacarbazine IV - Day 1

DRUG

Temozolomide

Temozolomide 200 mg/m2/day PO on Day 1 to Day 5 of each 28-day cycle

DRUG

Trametinib

Trametinib is an FDA approved anticancer medication that targets MEK1 and MEK2.

Trial Locations (59)

1502

RECRUITING

Sanatorium Profesora Arenbergera, Prague

2298

RECRUITING

Calvary Mater Newcastle, Waratah

3000

RECRUITING

Peter MacCallum Cancer Institute, Melbourne

3004

RECRUITING

Alfred Hospital, Melbourne

4102

RECRUITING

Princess Alexandra Hospital, Woolloongabba

4215

RECRUITING

Tasman Health Care, Southport

6009

RECRUITING

Hollywood Private Hospital, Nedlands

8025

RECRUITING

Isala Ziekenhuis, Amsterdam

9001

RECRUITING

APHP - Hopital Saint Louis, Paris

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

13005

RECRUITING

Assistance Publique Hopitaux de Marseille (AP-HM) - Hopital de la Timone, Marseille

20132

RECRUITING

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele (HSR) (Istituto Scientifico Universitario Sa, Milan

21079

RECRUITING

CHU Dijon Bourgogne - Hopital Francois Mitterand (Hopital du Bocage), Dijon

28007

RECRUITING

Hospital General Universitario Gregorio Marañón, Madrid

28034

RECRUITING

Hospital Universitario Ramon y Cajal, Madrid

28050

RECRUITING

Hospital HM Sanchinarro, Madrid

33011

ACTIVE_NOT_RECRUITING

Hospital Universitario Central de Asturias, Oviedo

33075

RECRUITING

Centre Hospitalier Universitaire (CHU) de Bordeaux - Hospitalier Saint-Andre, Bordeaux

33100

RECRUITING

Azienda Sanitaria Universitaria del Friuli Centrale, Udine

33136

RECRUITING

University of Miami Sylvester Cancer, Miami

37203

RECRUITING

SCRI Oncology Partners (formerly Tennessee Oncology), Nashville

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

48201

RECRUITING

Barbara Ann Karmanos Cancer Institute, Detroit

50005

RECRUITING

Fakultni nemocnice Hradec Kralove, Nový Hradec Králové

53792

RECRUITING

University of Wisconsin, Madison

59000

RECRUITING

CHRU de Lille - Hôpital Claude Huriez, Lille

63110

RECRUITING

Washington University School of Medicine, St Louis

65653

RECRUITING

Masarykuv Onkologicky Ustav-MOU, Brno

66205

RECRUITING

University of Kansas Cancer Center, Kansas City

69310

RECRUITING

Centre Hospitalier Lyon-Sud, Lyon

70121

RECRUITING

Mayo Clinic - Florida, Jacksonville

ACTIVE_NOT_RECRUITING

Ochsner Clinic Foundation, Jefferson

RECRUITING

Mayo Clinic, Rochester

72000

RECRUITING

Centre Hospitalier du Mans, Le Mans

75010

RECRUITING

Hospital Ambroise Pairs, Paris

75246

RECRUITING

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

78705

RECRUITING

Texas Oncology- Austin Midtown, Austin

80113

RECRUITING

The Melanoma and Skin Care Institute, Englewood

84112

RECRUITING

The University of Utah - Huntsman Cancer Institute (HCI), Salt Lake City

85054

RECRUITING

Mayo Clinic - Arizona, Phoenix

94143

RECRUITING

University of California, San Francisco, San Francisco

94805

RECRUITING

CLCC Institute Gustave Roussy, Villejuif

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

02114

RECRUITING

Massachusetts General Hospital, Boston

23502-1871

RECRUITING

Virginia Oncology Associates, Norfolk

B3J 3R4

RECRUITING

Queen Elizabeth II Health Sciences Centre, Halifax

H4A3J1

RECRUITING

McGill University Health Centre, Montreal

00144

RECRUITING

IRCCS Istituto Nazionale Tumori Regina Elena, Roma

00167

RECRUITING

Istituto Dermopatico dell Immacolata IDI-IRCCS, Roma

2333 ZC

RECRUITING

Leids Universitair Medisch Centrum, Leiden

6525 GA

RECRUITING

Radboud University, Nijmegen

08035

ACTIVE_NOT_RECRUITING

Hospital Universitari Vall d'Hebron - Vall d'Hebron Institut d'Oncologia (VHIO), Barcelona

08036

RECRUITING

Hospital Clinic de Barcelona, Barcelona

PR29H

RECRUITING

Royal Preston Hospital, Preston

W1G 6AD

RECRUITING

Sarah Cannon Research Institute - HCA Healthcare, City of London

EX25DW

RECRUITING

Royal Devon and Exeter Hospital, Exeter

SM2 5PT

ACTIVE_NOT_RECRUITING

The Royal Marsden NHS Foundation Trust, London

M20 4GJ

ACTIVE_NOT_RECRUITING

Christie Hospital, Manchester

All Listed Sponsors
lead

Erasca, Inc.

INDUSTRY