A Study of MK-1084 Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

PHASE3RecruitingINTERVENTIONAL
Enrollment

600

Participants

Timeline

Start Date

May 24, 2024

Primary Completion Date

February 19, 2029

Study Completion Date

February 18, 2031

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

MK-1084

Oral tablets

OTHER

Placebo

Oral tablets

BIOLOGICAL

Pembrolizumab

IV infusion

Trial Locations (192)

1023

RECRUITING

Auckland City Hospital ( Site 3400), Auckland

1100

RECRUITING

Lung Center of the Philippines-Pulmonary, Critical Care and Sleep Medicine ( Site 3503), Quezon City

RECRUITING

Veterans Memorial Medical Center-Section of Oncology ( Site 3505), Quezon City

1206

RECRUITING

Tbilisi Institute of Medicine ( Site 1206), Tbilisi

1210

RECRUITING

Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2400), Vienna

1632

RECRUITING

Multiprofile Hospital for Active Treatment Serdika EOOD-Second Department of Medical Oncology ( Site 1002), Sofia

2050

RECRUITING

Chris O'Brien Lifehouse ( Site 3000), Camperdown

3199

RECRUITING

Frankston Hospital ( Site 3002), Frankston

4500

RECRUITING

MBAL Uni Hospital-Department of Medical Oncology ( Site 1000), Panagyurishte

5804

RECRUITING

MHAT - Heart and Brain ( Site 1006), Pleven

6000

RECRUITING

High Technology Hospital Medcenter ( Site 1203), Batumi

6009

RECRUITING

One Clinical Research ( Site 3001), Nedlands

8036

RECRUITING

Medizinische Universität Graz-Klinische Abteilung für Pulmonologie ( Site 2401), Graz

12206

RECRUITING

New York Oncology Hematology, P.C. ( Site 0132), Albany

16247

RECRUITING

The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 3600), Suwon

18009

RECRUITING

"COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 2209)", Cherkasy

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1600), Milan

20141

RECRUITING

Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 1604), Milan

21000

RECRUITING

Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 1103), Dijon

21029

RECRUITING

"Communal Noncommercial Enterprise Podillia Regional Oncolog-Cardiothoracic department ( Site 2211)", Vinnytsia

21431

RECRUITING

The Catholic University of Korea, Incheon St. Mary's Hospital ( Site 3606), Bupyeong-gu

25011

RECRUITING

Kirovohrad Regional Oncology Center-Chemotherapy department ( Site 2204), Kropyvnytskyi

26504

RECRUITING

UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 1402), Pátrai

28009

RECRUITING

HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON-ONCOLOGY ( Site 2012), Madrid

28040

RECRUITING

Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 2017), Madrid

29011

RECRUITING

H.R.U Málaga - Hospital General-Oncology ( Site 2014), Málaga

33007

COMPLETED

Rivne Regional Clinical Hospital ( Site 2205), Rivne

33010

RECRUITING

ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2920), Rivne

33081

RECRUITING

CRO-IRCCS-Clinical Oncology ( Site 1605), Aviano

33140

RECRUITING

Mount Sinai Cancer Center ( Site 0137), Miami Beach

34214

RECRUITING

Medipol Mega Universite Hastanesi-oncology ( Site 2105), Istanbul

34722

RECRUITING

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2103), Istanbul

35001

RECRUITING

Hospital Insular de Gran Canaria-Oncology ( Site 2019), Las Palmas de Gran Canaria

35015

RECRUITING

Chungnam national university hospital ( Site 3602), Junggu

35100

RECRUITING

Ege Universitesi Hastanesi-Chest Diseases Department ( Site 2102), Bornova

35128

RECRUITING

Istituto Oncologico Veneto IRCCS-Oncologia 2 ( Site 1603), Padua

41009

RECRUITING

Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2015), Seville

42699

RECRUITING

Krankenhaus Bethanien ( Site 1303), Solingen

43018

RECRUITING

ME Volyn Regional Clinical Hospital of the Volyn Regional Council ( Site 2216), Lutsk

45219

RECRUITING

University of Cincinnati Medical Center-University of Cincinnati Cancer Center ( Site 0103), Cincinnati

45429

RECRUITING

Kettering Health Main Campus-Kettering Health Cancer Center ( Site 0106), Kettering

48121

RECRUITING

Ospedale Santa Maria delle Croci ( Site 1606), Ravenna

50000

RECRUITING

"Medical Center Mriya Med-Service-Clinical Research Department ( Site 2215)", Kryvyi Rih

50612

RECRUITING

Pusan National University Yangsan Hospital-Lung Cancer Clinic ( Site 3603), Yangsan

53715

RECRUITING

Circuit Clinical/SSM Health Dean Medical Group ( Site 0129), Madison

57124

RECRUITING

Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno-UOC Oncologia Medica Livorno ( Site 1608), Livorno

58013

RECRUITING

"Regional Municipal Non-profit Enterprise Bukovinian Clinica-structural unit of the clinical trials ( Site 2210)", Chernivtsi

58128

RECRUITING

Chonnam National University Hwasun Hospital-Pulmonology ( Site 3604), Hwasun

59102

RECRUITING

St. Vincent Frontier Cancer Center-Research ( Site 0105), Billings

59304

RECRUITING

Clinique Teissier Groupe ( Site 1100), Valenciennes

60077

RECRUITING

Orchard Healthcare Research Inc. ( Site 0115), Skokie

63003

RECRUITING

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 1101), Clermont-Ferrand

64108

RECRUITING

Truman Medical Center ( Site 0126), Kansas City

65807

RECRUITING

Cox Medical Center North ( Site 0133), Springfield

66460

RECRUITING

"Hospital Universitario Dr. Jose Eleuterio Gonzalez-Hematologia and Oncologia ( Site 0600)", Monterrey

68000

RECRUITING

Oaxaca Site Management Organization S.C. ( Site 0603), Oaxaca City

70199

RECRUITING

Marienhospital Stuttgart ( Site 1302), Stuttgart

76018

RECRUITING

"Communal Non-Commercial Enterprise Prykarpatski Clinical On-Surgery department #2 ( Site 2202)", Ivano-Frankivsk

77030

RECRUITING

Oncology Consultants P.A. ( Site 0113), Houston

79059

RECRUITING

"Municipal non-profit enterprise Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 2217)", Lviv

80131

RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia clinica sperimentale Toraco-Polmonare ( Site 1607), Napoli

RECRUITING

A.O.R.N. Ospedale dei Colli - Monaldi V.-U.O.C Pneumologia Oncologica DH PNL ONC ( Site 1602), Naples

84000

RECRUITING

Centre Hospitalier d'Avignon-Service d'Oncologie médicale et d'hématologie clinique ( Site 1104), Avignon

90211

RECRUITING

Beverly Hills Cancer Center ( Site 0116), Beverly Hills

92100

RECRUITING

Hôpital Ambroise Paré-Department of Respiratory Diseases and Thoracic Oncology ( Site 1105), Boulogne-Billancourt

93309

RECRUITING

CBCC Global Research, Inc. ( Site 0123), Bakersfield

100142

RECRUITING

Beijing Cancer hospital ( Site 3133), Beijing

RECRUITING

Beijing Cancer hospital ( Site 3134), Beijing

100730

RECRUITING

Beijing Peking Union Medical College Hospital-pneumology department ( Site 3102), Beijing

101149

RECRUITING

Beijing Chest Hospital,Capital Medical University ( Site 3104), Beijing

130000

RECRUITING

Jilin Province Tumor Hospital ( Site 3107), Changchun

150000

RECRUITING

Harbin Medical University Cancer Hospital ( Site 3123), Harbin

154007

RECRUITING

JIAMUSI TUBERCULOSIS HOSPITAL(CANCER HOSPITAL) ( Site 3124), Jiamusi

200030

RECRUITING

Shanghai Chest Hospital ( Site 3100), Shanghai

200032

RECRUITING

Fudan University Shanghai Cancer Center ( Site 3144), Shanghai

RECRUITING

Zhongshan Hospital,Fudan University ( Site 3143), Shanghai

200542

RECRUITING

Centrul de Oncologie Sfantul Nectarie-Medical ( Site 1994), Craiova

210008

RECRUITING

Nanjing Gulou Hospital ( Site 3122), Nanjing

210012

RECRUITING

Nanjing First Hospital ( Site 3154), Nanjing

214122

RECRUITING

Affiliated Hospital of Jiangnan University(Wuxi Fourth People's Hospital ) ( Site 3155), Wuxi

215006

RECRUITING

The First Affiliated Hospital of Soochow University ( Site 3146), Suzhou

230000

RECRUITING

Anhui Provincial Cancer Hospital ( Site 3136), Hefei

250117

RECRUITING

Shandong Cancer Hospital ( Site 3116), Jinan

276001

RECRUITING

LinYi Cancer Hospital ( Site 3111), Linyi

300239

RECRUITING

Cabinet Medical Oncomed ( Site 1998), Timișoara

310003

RECRUITING

The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3115), Hangzhou

310016

RECRUITING

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 3121), Hangzhou

317000

RECRUITING

Taizhou Hospital of Zhejiang Province ( Site 3145), Linhai

325015

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University ( Site 3151), Wenzhou

330000

RECRUITING

The Second Affiliated Hospital of Nanchang University ( Site 3139), Nanchang

330209

RECRUITING

The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 3138), Nanchang

350014

RECRUITING

Fujian Cancer Hospital ( Site 3127), Fuzhou

361003

RECRUITING

The First Affiliated hospital of Xiamen University ( Site 3148), Xiamen

400015

RECRUITING

Institutul Oncologic Cluj-Oncologie Medicala ( Site 1999), Cluj-Napoca

400030

RECRUITING

Chongqing University Cancer Hospital ( Site 3119), Chongqing

400042

RECRUITING

Army Medical Center of People's Liberation Army ( Site 3142), Chongqing

410011

RECRUITING

The Second Xiangya Hospital of Central South University ( Site 3130), Changsha

410013

RECRUITING

Hunan Cancer Hospital ( Site 3141), Changsha

430000

RECRUITING

Tongji Hospital Tongji Medical,Science & Technology ( Site 3113), Wuhan

430079

RECRUITING

Hubei Cancer Hospital ( Site 3126), Wuhan

450008

RECRUITING

Henan Cancer Hospital ( Site 3149), Zhengzhou

500052

RECRUITING

SC ONCO CARD SRL ( Site 1995), Brasov

510160

RECRUITING

The First Affiliated Hospital of Guangzhou Medical University ( Site 3108), Guangzhou

510515

RECRUITING

Southern Medical University Nanfang Hospital ( Site 3128), Guangzhou

510555

RECRUITING

Sun Yat-sen University Cancer Center ( Site 3137), Guangzhou

610031

RECRUITING

The Third People's Hospital of Chengdu (CDTPH) ( Site 3157), Chengdu

610041

RECRUITING

West China Hospital, Sichuan University ( Site 3140), Chengdu

610042

RECRUITING

Sichuan Cancer hospital. ( Site 3109), Chengdu

641000

RECRUITING

The Second People's Hospital of Neijiang ( Site 3105), Neijiang

650107

RECRUITING

Yunnan Province Cancer Hospital ( Site 3153), Kunming

710000

RECRUITING

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 3150), Xi'an

710038

RECRUITING

The Second Affiliated Hospital of Air Force Medical University ( Site 3117), Xian

RECRUITING

The Second Affiliated Hospital of Air Force Medical University ( Site 3152), Xian

720214

RECRUITING

Sigmedical Services SRL ( Site 1997), Suceava

830000

RECRUITING

Xinjiang Medical University Cancer Hospital - Urumqi ( Site 3101), Ürümqi

3465584

RECRUITING

Clinica Universidad Catolica del Maule-Oncology ( Site 0500), Talca

7500713

RECRUITING

Orlandi Oncologia-Oncology ( Site 0503), Santiago

7500921

RECRUITING

FALP-UIDO ( Site 0501), Santiago

7560908

RECRUITING

Centro de Oncología de Precisión-Oncology ( Site 0502), Santiago

8420383

RECRUITING

Bradfordhill-Clinical Area ( Site 0504), Santiago

07960

RECRUITING

Atlantic Health System Morristown Medical Center ( Site 0121), Morristown

C1019ABS

COMPLETED

AUSTRAL MEDICAL CENTER ( Site 0302), CABA

C1426AGE

RECRUITING

Centro Oncologico Korben ( Site 0304), CABA

B7600FZO

RECRUITING

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0300), Mar del Plata

S2000DEJ

RECRUITING

Fundacion Estudios Clinicos ( Site 0306), Rosario

S2000DVC

RECRUITING

Sanatorio Parque ( Site 0301), Rosario

30380-472

RECRUITING

Hospital Mario Penna ( Site 0436), Belo Horizonte

50040-000

RECRUITING

Hospital de Câncer de Recife ( Site 0447), Recife

64049-200

RECRUITING

Oncoclínica Oncologistas Associados ( Site 0441), Teresina

59062-000

RECRUITING

Liga Norte Riograndense Contra o Câncer ( Site 0439), Natal

90050-170

RECRUITING

Irmandade da Santa Casa de Misericórdia de Porto Alegre-Centro Multidisciplinar de Pesquisa Clínica ( Site 0435), Porto Alegre

14784-400

RECRUITING

Fundação Pio XII - Hospital de Câncer de Barretos-Unidade de Pesquisa Clínica ( Site 0437), Barretos

20230-130

RECRUITING

Instituto Nacional de Câncer - INCA ( Site 0446), Rio de Janeiro

22775-001

RECRUITING

Americas ( Site 0431), Rio de Janeiro

R3E 0V9

RECRUITING

CancerCare Manitoba ( Site 0210), Winnipeg

B3H 2Y9

RECRUITING

QEII Health Sciences Centre - Victoria General Site-Dept. of Medical Oncology ( Site 0208), Halifax

L8V 5C2

RECRUITING

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0205), Hamilton

M4N 3M5

RECRUITING

Sunnybrook Research Institute ( Site 0206), Toronto

H3T 1M5

RECRUITING

St. Marys Hospital Center ( Site 0204), Montreal

G8Z 3R9

RECRUITING

Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0207), Trois-Rivières

030000

RECRUITING

Shanxi Cancer Hospital ( Site 3131), Taiyuan

0186

RECRUITING

Caucasus Medical Centre ( Site 1202), Tbilisi

0102

RECRUITING

American Hospital Network LLC ( Site 1208), Tbilisi

0112

RECRUITING

Todua Clinic, LLC ( Site 1204), Tbilisi

0144

RECRUITING

TSMU and Ingorokva High Medical Technology University Clinic LTD ( Site 1201), Tbilisi

0162

RECRUITING

New Hospitals ( Site 1200), Tbilisi

0177

RECRUITING

Cancer Research Centre. Mardaleishvili Medical Centre ( Site 1205), Tbilisi

115 27

RECRUITING

"THORACIC GENERAL HOSPITAL OF ATHENS I SOTIRIA-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1400)", Athens

411 10

RECRUITING

University General Hospital of Larissa-Oncology Clinic ( Site 1403), Larissa

552 36

RECRUITING

Agios Loukas Clinic ( Site 1404), Thessaloniki

570 10

RECRUITING

G. Papanikolaou General Hospital-Pulmonary Clinic of Aristotle University of Thessaloniki ( Site 1405), Thessaloniki

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1601), Rome

00144

RECRUITING

Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1609), Rome

466-8560

RECRUITING

Nagoya University Hospital ( Site 3309), Nagoya

470-1192

RECRUITING

Fujita Health University Hospital ( Site 3310), Toyoake

719-0280

RECRUITING

National Hospital Organization Shikoku Cancer Center ( Site 3315), Matsuyam

811-1395

RECRUITING

National Hospital Organization Kyushu Cancer Center ( Site 3316), Fukuoka

830-0011

RECRUITING

Kurume University Hospital ( Site 3317), Kurume

373-8550

RECRUITING

Gunma Prefectural Cancer Center ( Site 3302), Ōta

920-8641

RECRUITING

Kanazawa University Hospital ( Site 3308), Kanazawa

216-8511

RECRUITING

St. Marianna University Hospital ( Site 3320), Kawasaki

515-8544

RECRUITING

Matsusaka Municipal Hospital ( Site 3311), Matsusaka

981-1293

RECRUITING

Miyagi Cancer Center ( Site 3301), Natori-shi

981-0914

RECRUITING

Sendai Kousei Hospital ( Site 3300), Sendai

573-1191

RECRUITING

Kansai Medical University Hospital ( Site 3312), Hirakata

569-8686

RECRUITING

Osaka Medical and Pharmaceutical University Hospital ( Site 3313), Takatsuki

362-0806

RECRUITING

Saitama Prefectural Cancer Center ( Site 3304), Kitaadachi-gun

113-8603

RECRUITING

Nippon Medical School Hospital ( Site 3306), Bunkyo

143-8541

RECRUITING

Toho University Omori Medical Center ( Site 3319), Ōta-ku

160-0023

RECRUITING

Tokyo Medical University Hospital ( Site 3307), Shinjuku

162-8655

RECRUITING

National Center for Global Health and Medicine ( Site 3305), Shinjuku

260-8677

RECRUITING

Chiba University Hospital ( Site 3322), Chiba

730-8518

RECRUITING

Hiroshima City Hiroshima Citizens Hospital ( Site 3314), Hiroshima

861-4193

RECRUITING

Saiseikai Kumamoto Hospital ( Site 3318), Kumamoto

545-8586

RECRUITING

Osaka Metropolitan University Hospital ( Site 3321), Osaka

06700

RECRUITING

Arké SMO S.A. de C.V. ( Site 0602), Mexico City

3844 DG

RECRUITING

Ziekenhuis St. Jansdal-Poli Longziekten ( Site 1701), Harderwijk

8025 AB

RECRUITING

Isala, locatie Zwolle-Poli Longziekten ( Site 1700), Zwolle

3584 CX

RECRUITING

Universitair Medisch Centrum Utrecht ( Site 1704), Utrecht

38-300

RECRUITING

Szpital Specjalistyczny im. Henryka Klimontowicza ( Site 1801), Gorlice

30-727

RECRUITING

Pratia MCM Krakow ( Site 1808), Krakow

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1800), Warsaw

37-700

RECRUITING

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1804), Przemyśl

02447

RECRUITING

Kyung Hee University Hospital ( Site 3605), Seoul

08308

RECRUITING

Korea University Guro Hospital ( Site 3601), Seoul

08035

RECRUITING

Hospital Universitari Vall d Hebron ( Site 2010), Barcelona

01140

RECRUITING

Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2107), Adana

06010

RECRUITING

SBU GULHANE EGITIM VE ARASTIRMA HASTANESI Onkoloji ( Site 2104), Ankara

06230

RECRUITING

Hacettepe Universite Hastaneleri-oncology hospital ( Site 2101), Ankara

06520

RECRUITING

Memorial Ankara Hastanesi-Medical Oncology ( Site 2106), Ankara

06800

RECRUITING

Ankara Bilkent Şehir Hastanesi ( Site 2100), Ankara

03022

RECRUITING

"Medical Center MedOffice Group ( Site 2219)", Kiev

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY