The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury

NARecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

April 5, 2024

Primary Completion Date

August 5, 2024

Study Completion Date

August 18, 2024

Conditions
Myocardial Injury After Non-cardiac SurgeryHypotension During SurgeryAnesthesia, GeneralAnesthesia, Spinal
Interventions
PROCEDURE

General Anesthesia

After preoxygenation, intravenous fentanyl (1 μg/kg), propofol (2 mg/kg), and rocuronium (0.6 mg/kg) will be used for anesthesia induction. Intubation will be performed with a 7.0-8.0 sized tube, followed by the initiation of mechanical ventilation (tidal volume: 6-8 ml/kg, respiratory rate: 12 breaths/min). Sevoflurane will be used to maintain anesthesia (0.7-1 MAC), and remifentanil infusion will be administered for analgesia. Postoperatively, tramadol (1 mg/kg) and paracetamol (10 mg/kg) will be administered intravenously. Neuromuscular blockade will be reversed using sugammadex. Patients with an Aldrete Recovery Score ≥9 will be transferred to the post-anesthesia care unit after extubation.

PROCEDURE

Spinal Anesthesia

Patients will be positioned laterally with the hip to be operated on the lower side, and skin asepsis will be ensured, followed by sterile draping. A dural puncture will be performed at the L3-4 spinal level using a 22-25 gauge Quincke-tip spinal needle. After the detection of cerebrospinal fluid, 7.5 mg of 0.5% hyperbaric bupivacaine will be slowly injected. Following a 10-minute interval, the sensory block level will be assessed using the pinprick test and modified Bromage scale, aiming for a T10 sensory block. Surgery will commence upon achieving adequate sensory block. Postoperatively, patients will be transferred to the recovery room. Patients failing to attain sufficient sensory block and experiencing pain will undergo transition to general anesthesia, terminating their cases.

Trial Locations (1)

34396

RECRUITING

Sisli Hamidiye Etfal Training and Research Hospital, Istanbul

All Listed Sponsors
lead

Sisli Hamidiye Etfal Training and Research Hospital

OTHER