Efficacy and Safety of Concurrent PD-1 Inhibitor and Radiotherapy With Immunonutrition for Esophageal Squamous Cell Carcinoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

57

Participants

Timeline

Start Date

March 14, 2024

Primary Completion Date

July 1, 2026

Study Completion Date

December 1, 2026

Conditions
Locally Advanced Esophageal Squamous Cell CarcinomaSintilimabRadiotherapyConcurrent ChemoradiotherapyImmunonutrition
Interventions
RADIATION

Radiotherapy

Interventions consist of 50-60 Gy in 25-30 fractions of radiotherapy.

DRUG

Programmed Cell Death Protein 1 Inhibitor

200 mg of Sintilimab administered every three weeks concurrently with radiotherapy and after radiotherapy as consolidation therapy up to 1year.

DIETARY_SUPPLEMENT

Immunonutrition support

600-1600 ml of TPF-T per day according to the nutrition status evaluation

Trial Locations (9)

100021

Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing

317000

Taizhou hospital of Wenzhou Medical University, Taizhou

Unknown

Department of Radiation Oncology,Clinical Oncology School of Fujian Medical University,Fujian Cancer Hospital, Fujian

Department of Oncology, Affiliated Hospital, Hebei University of Engineering, Handan

Department 1st of Radiation Oncology, Anyang Tumor Hospital, Anyang

Department of Radiation Oncology the first affiliated hospital of Xinxiang Medical University, Xinxiang

Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan

Department of Radiation Oncology,Fei County People's Hospital, Feixian

Department of Radiation Oncology, Affiliated hospital of Jining Medical University, Jining

All Listed Sponsors
lead

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

OTHER