Effects of Maintenance Cabozantinib+BSC Versus BSC in Children and AYA With Osteosarcoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

November 22, 2024

Primary Completion Date

October 26, 2026

Study Completion Date

June 15, 2028

Conditions
OsteosarcomaOsteosarcoma in ChildrenOsteosarcoma in Adolescents and Young Adults
Interventions
DRUG

Cabozantinib

Participants will receive cabozantinib orally Once daily (QD) on a continuous dosing schedule for cycles of 28 days.

OTHER

Best Supportive Care (BSC)

Participants will receive BSC. BSC includes antibiotics, nutritional support, correction of metabolic disorders, optimal symptom control and pain management (including palliative radiotherapy), etc. but does not include tumor specific therapy.

OTHER

Best Supportive Care (BSC)

Participants will receive BSC alone. BSC includes antibiotics, nutritional support, correction of metabolic disorders, optimal symptom control and pain management (including palliative radiotherapy), etc. but does not include tumor specific therapy.

Trial Locations (75)

23507

TERMINATED

Children's Hospital of the King's Daughters, Norfolk

28203

RECRUITING

Levine Children's Hospital (LCH), Charlotte

32610

RECRUITING

University of Florida Health Shands Children's Hospital, Gainesville

45229

RECRUITING

Cincinnati Children's Hospital Medical Center - Cancer and Blood Diseases Institute (CBDI), Cincinnati

77030

RECRUITING

MD Anderson Main Campus, Houston

90033

NOT_YET_RECRUITING

University of Southern California (USC) - Norris Cancer Hospital, Los Angeles

94304

RECRUITING

Stanford University and Lucile Packard Children's Hospital, Palo Alto

Unknown

RECRUITING

St. Anna Kinderspital Zentrum fuer Kinder- und Jugendheilkunde, Vienna

RECRUITING

Cliniques universitaires Saint-Luc, Brussels

RECRUITING

University Hospital Gent, Ghent

RECRUITING

Universitaire Ziekenhuizen Leuven, Leuven

NOT_YET_RECRUITING

Arthur J. E. Child Comprehensive Cancer Centre, Calgary

NOT_YET_RECRUITING

McGill University Health Centre - Centre for Innovative Medicine, Québec

RECRUITING

Princess Margaret cancer center, Toronto

RECRUITING

Sinai Health System-Mount Sinai Hospital, Toronto

RECRUITING

Aarhus University Hospital, Aarhus

RECRUITING

Copenhagen University Hospital - Rigshospitalet, Copenhagen

RECRUITING

Institut Bergonie, Bordeaux

RECRUITING

Centre Francois Baclesse, Caen

TERMINATED

Centre Oscar Lambret, Lille

NOT_YET_RECRUITING

Centre Leon Berard, Lyon

RECRUITING

CHU de Nantes, Nantes

RECRUITING

AP-HP Hopital Cochin, Paris

NOT_YET_RECRUITING

Institut Curie, Paris

RECRUITING

CHU de Poitiers (Poitiers), Poitiers

NOT_YET_RECRUITING

CHU de Poitiers, Poitiers

RECRUITING

CHU de Rouen - Hôpital Charles-Nicolle, Rouen

RECRUITING

CHRU de Strasbourg - Hopital de Hautepierre, Strasbourg

RECRUITING

CHU de Toulouse - Hôpital des Enfants, Toulouse

RECRUITING

Gustave Roussy, Villejuif

NOT_YET_RECRUITING

Charité - Kinderonkologie, Berlin

RECRUITING

Universitaetsklinikum Köln - Kinderonkologie, Cologne

RECRUITING

Klinikum Dortmund, Dortmund

RECRUITING

Universitaetsklinikum Carl Gustav Carus Dresden, Dresden

RECRUITING

Universitätsklinikum Essen Westdeutsches Tumorzentrum Essen, Essen

RECRUITING

Klinikum Kassel Gesundheit Nordhessen, Kassel

RECRUITING

Universitätsmedizin Mainz, Mainz

TERMINATED

Dr. von Haunerschen Kinderspital, München

NOT_YET_RECRUITING

Klinikum rechts der Isar der Technischen Universitaet Muenchen, München

RECRUITING

Medizinischen Klinik III - Onkologie und Hämatologie - am LMU Klinikum, München, München

RECRUITING

Olgahospital, Stuttgart

RECRUITING

St Vincent's University Hospital, Dublin

RECRUITING

Ospedale Ortopedico Rizzoli di Bologna, Bologna

RECRUITING

Istituto Di Candiolo Fondazione Del Piemonte Per L'oncologia IRCCS, Candiolo

RECRUITING

Azienda Ospedaliero Universitaria Meyer, Florence

RECRUITING

IRCCS Istituto Giannina Gaslini, Genova

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

RECRUITING

Istituto Nazionale Tumor, Naples

RECRUITING

Azienda Ospedale - Università Padova, Padua

TERMINATED

AOU Città della Salute e della Scienza di Torino, Piemonte

RECRUITING

IRCCS - Istituto Nazionale Tumori Regina Elena, Roma

RECRUITING

Ospedale Paediatrico Bambino Gesù, Roma

NOT_YET_RECRUITING

Azienda Ospedaliero-Universitaria Senese, Siena

RECRUITING

AOU Citta della Salute e della Scienza di Torino - Ospedale Regina Margherita, Torino

RECRUITING

Amsterdam UMC - Locatie AMC, Amsterdam

RECRUITING

Princess Maxima Center for paediatric oncology, Utrecht

RECRUITING

Instytut Matki i Dziecka, Warsaw

RECRUITING

Hospital de La Santa Creu i Sant Pau, Barcelona

RECRUITING

Hospital Sant Joan de Deu, Barcelona

RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona

RECRUITING

Hospital Universitario La Paz, Castellana

RECRUITING

Hospital General Unversitario Gregorio Marañón (Madrid), Madrid

RECRUITING

Hospital General Unversitario Gregorio Marañón, Madrid

RECRUITING

Hospital Infantil Universitario Nino Jesus, Madrid

RECRUITING

Hospital Universitario Son Espases, Palma de Mallorca

RECRUITING

Complejo Hospitalario Universitario de Santiago, Santiago de Compostela

RECRUITING

Hospital Universitario Virgen del Rocio, Seville

RECRUITING

Hospital Universitari i Politecnic La Fe, Valencia

RECRUITING

Karolinska University Hospital, Stockholm

TERMINATED

Birmingham Children's Hospital, Birmingham

RECRUITING

Cambridge University Hospitals NHS Trust, Cambridge

NOT_YET_RECRUITING

NHS greater Glasgow and Clyde, Glasgow

RECRUITING

University College London Hospital, London

RECRUITING

Christie NHS Foundation Trust, Manchester

NOT_YET_RECRUITING

Royal Victoria Infirmary, Newcastle upon Tyne

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Ipsen

INDUSTRY