Pulsed Electromagnetic Fields (PEMFs) - A Highly Selective Breast CAncer Treatment pLatform (PASCAL)

PHASE1RecruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

December 30, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Breast Cancer
Interventions
DEVICE

Pulsed electromagnetic fields (PEMFs)

"Device: PEMFs~PEMFs treatment can be delivered up to 7 days prior to day of surgery (dose levels 1-2) or anthracycline-based chemotherapy (dose levels 3-4) to allow subject flexibility of timing and decrease the need for multiple visits. A research staff will be assigned to be with subject during the duration of PEMFs to monitor for any side effects during treatment."

DRUG

Anthracycline-based chemotherapy

"Drug: Anthracycline-based chemotherapy (doxorubicin, cyclophosphamide)~At dose levels 3 and 4, two cohorts will be opened: the first cohort will undergo surgical resection immediately after completion of anthracycline-based chemotherapy, and the second cohort will undergo taxane-based chemotherapy following completion of anthracycline-based chemotherapy."

Trial Locations (1)

119074

RECRUITING

National University Hospital, Singapore

All Listed Sponsors
collaborator

National University of Singapore

OTHER

lead

National University Hospital, Singapore

OTHER