Gut Oxalate Absorption in Calcium Oxalate Stone Disease

NARecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

April 17, 2024

Primary Completion Date

December 31, 2030

Study Completion Date

December 31, 2031

Conditions
Kidney StoneKidney CalculiUrolithiasisUrolithiasis, Calcium OxalateNephrolithiasisNephrolithiasis, Calcium OxalateOxalate UrolithiasisOxaluriaHealthy
Interventions
DIETARY_SUPPLEMENT

Low-oxalate diet

4 days of fixed eucaloric diet with low oxalate (\<60 mg/day), normal calcium content (600-1000 mg/day)

DIETARY_SUPPLEMENT

High-oxalate diet

4 days of fixed eucaloric diet with moderately high oxalate (250-300 mg/day), normal calcium content (600-1000 mg/day)

OTHER

soluble oxalate gut absorption test

Oral ingestion of 13C2-oxalate and sucralose.

Trial Locations (2)

35294

RECRUITING

University of Alabama at Birmingham, Birmingham

75390

ACTIVE_NOT_RECRUITING

UTSW, Dallas

All Listed Sponsors
collaborator

University of Texas Southwestern Medical Center

OTHER

collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

lead

University of Alabama at Birmingham

OTHER