Mechanisms of Pulmonary Vascular Dysfunction in Heart Failure

RecruitingOBSERVATIONAL
Enrollment

230

Participants

Timeline

Start Date

August 23, 2024

Primary Completion Date

December 30, 2026

Study Completion Date

December 30, 2026

Conditions
Heart FailurePulmonary HypertensionPulmonary Vascular Resistance Abnormality
Interventions
DIAGNOSTIC_TEST

non-contrast chest CT

patients who undergo clinically indicated evaluation of pulmonary circulation (right heart catheterisation - RHC) will undergo non-contrast CT of the chest, blood sampling from pulmonary artery and spirometry with DLCO analysis.

DIAGNOSTIC_TEST

spirometry with diffusing lung capacity for carbon monoxide (DLCO) analysis

patients who undergo clinically indicated evaluation of pulmonary circulation (RHC) will undergo non-contrast CT of the chest, blood sampling from pulmonary artery and spirometry with DLCO analysis.

DIAGNOSTIC_TEST

Omics analysis of blood plasma obtained from pulmonary artery or peripheral blood

patients who undergo clinically indicated evaluation of pulmonary circulation (RHC) will undergo non-contrast CT of the chest, blood sampling from pulmonary artery and spirometry with DLCO analysis.

DIAGNOSTIC_TEST

supine bike exercise during right heart catheterisation

subgroup of HF subjects who undergo right heart catheterisation will perform short supine bike exercise during RHC

DIAGNOSTIC_TEST

Lung ventilation/perfusion SPECT

subgroup of HF subjects will undergo ventilation/perfusion SPECT

Trial Locations (1)

140 21

RECRUITING

Institute for Clinical and Experimental Medicine - IKEM, Prague

All Listed Sponsors
lead

Institute for Clinical and Experimental Medicine

OTHER_GOV