Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients

NARecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

July 1, 2024

Primary Completion Date

July 30, 2027

Study Completion Date

November 30, 2027

Conditions
Moyamoya DiseaseMoyamoya
Interventions
DIAGNOSTIC_TEST

MRI

Patients will get special MRI sequences (CO2-triggered BOLD MRI, Vessel-wall imaging, resting state BOLD MRI) to identify cerebral vasoreactivity and disease activity.

DIAGNOSTIC_TEST

H2 15O PET/CT

Patients will get H2 15O PET/CT with acetazolamide challenge to define the cerebral vasoreserve for comparison with fMRI Images

OTHER

Biosampling

Patients do get a venous puncture for blood analysis on circulating endothelial cells and virus PCR analysis

Trial Locations (1)

72076

RECRUITING

University of Tuebingen, Neurosurgery, Tübingen

All Listed Sponsors
collaborator

University Hospital Freiburg

OTHER

lead

University Hospital Tuebingen

OTHER