Evaluation of Cirrhotic Cardiomyopathy by Cardiac MRI in Patients Waiting for Liver Transplant.

Not yet recruitingOBSERVATIONAL
Enrollment

60

Participants

Timeline

Start Date

September 1, 2024

Primary Completion Date

September 1, 2025

Study Completion Date

June 1, 2027

Conditions
Cirrhosis
Interventions
DIAGNOSTIC_TEST

MRI

The examination lasts between 45 minutes and one hour. The patient lies down in the MRI tube. He is fitted with headphones that muffle the noise produced by the machine and enable him to receive instructions from the technician. Four electrodes are applied to his chest to continuously record his heartbeat. Finally, his chest is covered with a plastic plate, which receives the MRI signals needed to form the image. Acquiring an MRI image takes between 2 and 20 seconds. To ensure that image quality is not impaired by respiratory movements, images are acquired in apnea. The technician will ask the patient to hold his or her breath repeatedly throughout the examination.

BIOLOGICAL

Blood sampling

Additional blood will be drawn for dosing acylcarnitines, copeptin, interleukin-6 (IL-6), LPS-Binding Protein (LBP), Phospholipid TransferProtein (PLTP)/Cholesteryl Ester Tranfer Protein (CETP) activity, and for plasma banking. The volume of blood will be 20 ml in total (5 ml for each assay) at each visit. Patients participating in this study will have 3 visits. Total blood volume will therefore be 20 x 3, or 60 ml for the 3 visits.

Trial Locations (4)

21000

CHU Dijon - Hopital François Mitterrand, Dijon

25000

CHU Besancon - Hopital Minjoz, Besançon

54000

CHRU Nancy - Hôpital de Brabois, Nancy

67000

CHU Strasbourg - Hopital de HautePierre, Strasbourg

All Listed Sponsors
lead

Centre Hospitalier Universitaire de Besancon

OTHER