Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

184

Participants

Timeline

Start Date

November 8, 2024

Primary Completion Date

July 15, 2028

Study Completion Date

July 15, 2028

Conditions
Progressive GlioblastomaRecurrent Glioblastoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

Lomustine

Given PO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Nivolumab

Given IV

BIOLOGICAL

Relatlimab

Given IV

PROCEDURE

Surgical Procedure

Undergo surgery

Trial Locations (225)

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10032

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10461

RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

11042

RECRUITING

Northwell Health/Center for Advanced Medicine, Lake Success

11501

RECRUITING

NYU Langone Hospital - Long Island, Mineola

11706

RECRUITING

Northwell Health Imbert Cancer Center, Bay Shore

12801

RECRUITING

Glens Falls Hospital, Glens Falls

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15025

RECRUITING

Jefferson Hospital, Jefferson Hills

15090

RECRUITING

Wexford Health and Wellness Pavilion, Wexford

15146

RECRUITING

Forbes Hospital, Monroeville

15212

RECRUITING

Allegheny General Hospital, Pittsburgh

15224

RECRUITING

West Penn Hospital, Pittsburgh

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

16544

RECRUITING

Saint Vincent Hospital, Erie

18017

RECRUITING

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

RECRUITING

Lehigh Valley Hospital-Cedar Crest, Allentown

18301

RECRUITING

Pocono Medical Center, East Stroudsburg

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19713

RECRUITING

Helen F Graham Cancer Center, Newark

RECRUITING

Medical Oncology Hematology Consultants PA, Newark

19967

RECRUITING

Beebe South Coastal Health Campus, Millville

19971

RECRUITING

Beebe Health Campus, Rehoboth Beach

22031

RECRUITING

Inova Schar Cancer Institute, Fairfax

28374

RECRUITING

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst

29425

RECRUITING

Medical University of South Carolina, Charleston

32207

RECRUITING

Baptist MD Anderson Cancer Center, Jacksonville

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

32806

RECRUITING

Orlando Health Cancer Institute, Orlando

33021

RECRUITING

UM Sylvester Comprehensive Cancer Center at Hollywood, Hollywood

33065

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Springs, Coral Springs

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33166

RECRUITING

UM Sylvester Comprehensive Cancer Center at Doral, Doral

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

45069

RECRUITING

University of Cincinnati Cancer Center-West Chester, West Chester

45219

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

46237

RECRUITING

Franciscan Health Indianapolis, Indianapolis

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48118

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

49829

RECRUITING

OSF Saint Francis Hospital and Medical Group, Escanaba

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50036

RECRUITING

McFarland Clinic - Boone, Boone

50129

RECRUITING

McFarland Clinic - Jefferson, Jefferson

50158

RECRUITING

McFarland Clinic - Marshalltown, Marshalltown

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

Broadlawns Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50501

RECRUITING

McFarland Clinic - Trinity Cancer Center, Fort Dodge

RECRUITING

UI Healthcare Mission Cancer and Blood - Fort Dodge, Fort Dodge

51401

RECRUITING

Saint Anthony Regional Hospital, Carroll

52242

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

52403

RECRUITING

Mercy Hospital, Cedar Rapids

RECRUITING

Oncology Associates at Mercy Medical Center, Cedar Rapids

52722

RECRUITING

University of Iowa Healthcare Cancer Services Quad Cities, Bettendorf

53022

RECRUITING

Aurora Health Care Germantown Health Center, Germantown

53024

RECRUITING

Aurora Cancer Care-Grafton, Grafton

53066

RECRUITING

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

RECRUITING

Aurora Medical Center in Summit, Summit

53081

RECRUITING

Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan

RECRUITING

Sheboygan Physicians Group, Sheboygan

RECRUITING

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

RECRUITING

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53110

RECRUITING

Aurora Saint Luke's South Shore, Cudahy

53142

RECRUITING

Aurora Cancer Care-Kenosha South, Kenosha

53149

RECRUITING

ProHealth D N Greenwald Center, Mukwonago

53188

RECRUITING

ProHealth Waukesha Memorial Hospital, Waukesha

RECRUITING

UW Cancer Center at ProHealth Care, Waukesha

53209

RECRUITING

Aurora Cancer Care-Milwaukee, Milwaukee

53215

RECRUITING

Aurora Saint Luke's Medical Center, Milwaukee

53226

RECRUITING

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

RECRUITING

Aurora West Allis Medical Center, West Allis

53233

RECRUITING

Aurora Sinai Medical Center, Milwaukee

53406

RECRUITING

Aurora Cancer Care-Racine, Racine

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54143

RECRUITING

Aurora Bay Area Medical Group-Marinette, Marinette

54154

RECRUITING

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54241

RECRUITING

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54311

RECRUITING

Aurora BayCare Medical Center, Green Bay

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54806

RECRUITING

Duluth Clinic Ashland, Ashland

54904

RECRUITING

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

56401

RECRUITING

Essentia Health Saint Joseph's Medical Center, Brainerd

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

58103

RECRUITING

Essentia Health Cancer Center-South University Clinic, Fargo

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59711

RECRUITING

Community Hospital of Anaconda, Anaconda

59715

RECRUITING

Bozeman Health Deaconess Hospital, Bozeman

59804

RECRUITING

Community Medical Center, Missoula

59901

RECRUITING

Logan Health Medical Center, Kalispell

60010

RECRUITING

Advocate Good Shepherd Hospital, Barrington

60014

RECRUITING

AMG Crystal Lake - Oncology, Crystal Lake

60026

RECRUITING

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60048

RECRUITING

AMG Libertyville - Oncology, Libertyville

RECRUITING

Condell Memorial Hospital, Libertyville

60068

RECRUITING

Advocate Lutheran General Hospital, Park Ridge

60123

RECRUITING

Advocate Sherman Hospital, Elgin

60201

RECRUITING

NorthShore University HealthSystem-Evanston Hospital, Evanston

60429

RECRUITING

Advocate South Suburban Hospital, Hazel Crest

60453

RECRUITING

Advocate Outpatient Center - Oak Lawn, Oak Lawn

60463

RECRUITING

Advocate High Tech Medical Park, Palos Heights

60506

RECRUITING

Advocate Outpatient Center - Aurora, Aurora

60515

RECRUITING

Advocate Good Samaritan Hospital, Downers Grove

60612

RECRUITING

Rush MD Anderson Cancer Center, Chicago

RECRUITING

University of Illinois, Chicago

60657

RECRUITING

Advocate Illinois Masonic Medical Center, Chicago

61021

RECRUITING

Illinois CancerCare-Dixon, Dixon

61350

RECRUITING

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

RECRUITING

Illinois CancerCare-Peru, Peru

61356

RECRUITING

Illinois CancerCare-Princeton, Princeton

61401

RECRUITING

Illinois CancerCare-Galesburg, Galesburg

61443

RECRUITING

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

RECRUITING

Illinois CancerCare-Macomb, Macomb

61520

RECRUITING

Illinois CancerCare-Canton, Canton

61530

RECRUITING

Illinois CancerCare-Eureka, Eureka

61554

RECRUITING

Illinois CancerCare-Pekin, Pekin

61571

RECRUITING

Illinois CancerCare - Washington, Washington

61615

RECRUITING

Illinois CancerCare-Peoria, Peoria

61704

RECRUITING

Illinois CancerCare-Bloomington, Bloomington

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

RECRUITING

Memorial Hospital East, Shiloh

62321

RECRUITING

Illinois CancerCare-Carthage, Carthage

62401

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

66211

RECRUITING

University of Kansas Hospital-Indian Creek Campus, Overland Park

68118

RECRUITING

Nebraska Medicine-Village Pointe, Omaha

68123

RECRUITING

Nebraska Medicine-Bellevue, Bellevue

68198

RECRUITING

University of Nebraska Medical Center, Omaha

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

80524

RECRUITING

Poudre Valley Hospital, Fort Collins

80528

RECRUITING

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

RECRUITING

Medical Center of the Rockies, Loveland

80631

RECRUITING

UCHealth Greeley Hospital, Greeley

80909

RECRUITING

UCHealth Memorial Hospital Central, Colorado Springs

80920

RECRUITING

Memorial Hospital North, Colorado Springs

83605

RECRUITING

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

RECRUITING

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

RECRUITING

Saint Luke's Cancer Institute - Meridian, Meridian

83687

RECRUITING

Saint Alphonsus Cancer Care Center-Nampa, Nampa

RECRUITING

Saint Luke's Cancer Institute - Nampa, Nampa

83706

RECRUITING

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

90027

RECRUITING

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

90813

RECRUITING

City of Hope at Long Beach Elm, Long Beach

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

91786

RECRUITING

City of Hope Upland, Upland

92120

RECRUITING

Kaiser Permanente-San Diego Zion, San Diego

93534

RECRUITING

City of Hope Antelope Valley, Lancaster

94301

RECRUITING

Palo Alto Medical Foundation Health Care, Palo Alto

94598

RECRUITING

John Muir Medical Center-Walnut Creek, Walnut Creek

95602

RECRUITING

Sutter Auburn Faith Hospital, Auburn

95661

RECRUITING

Sutter Roseville Medical Center, Roseville

95816

RECRUITING

Sutter Medical Center Sacramento, Sacramento

97030

RECRUITING

Legacy Mount Hood Medical Center, Gresham

97062

RECRUITING

Legacy Meridian Park Hospital, Tualatin

97210

RECRUITING

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

97914

RECRUITING

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98684

RECRUITING

Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver

98686

RECRUITING

Legacy Salmon Creek Hospital, Vancouver

06606

RECRUITING

Hartford HealthCare - Saint Vincent's Medical Center, Bridgeport

06102

RECRUITING

Hartford Hospital, Hartford

06520

RECRUITING

Yale University, New Haven

06611

RECRUITING

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

60453-2699

RECRUITING

Advocate Christ Medical Center, Oak Lawn

04412

RECRUITING

Lafayette Family Cancer Center-EMMC, Brewer

04106

RECRUITING

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland

02111

RECRUITING

Tufts Medical Center, Boston

07601

RECRUITING

Hackensack University Medical Center, Hackensack

07960

RECRUITING

Morristown Medical Center, Morristown

07753

RECRUITING

Jersey Shore Medical Center, Neptune City

08080

RECRUITING

Sidney Kimmel Cancer Center Washington Township, Sewell

07902

RECRUITING

Overlook Hospital, Summit

05401

RECRUITING

University of Vermont Medical Center, Burlington

05405

RECRUITING

University of Vermont and State Agricultural College, Burlington

54235-1495

RECRUITING

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH