Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease

RecruitingOBSERVATIONAL
Enrollment

20

Participants

Timeline

Start Date

January 20, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Pediatric ALLCongenital Heart DiseaseHeart Transplantation
Interventions
DIAGNOSTIC_TEST

Exercise cardiac MRI Assessment

Participants will undergo a standard cardiac MRI to assess resting ventricular structure and function then complete an exercise cardiac MRI assessment using an MRI-compatible stepping ergometer.

DIAGNOSTIC_TEST

Cardiopulmonary Exercise Test

Cardiopulmonary exercise testing will be performed using a cycle ergometer. Consistent with standard guidelines, workload will progressively increase (10W ramp protocol) such that peak oxygen consumption (VO2peak) is achieved within 8-12 minutes. VO2peak, VO2 at anaerobic threshold, peak power output (PPO), ventilation/carbon dioxide production (VE/VCO2) slope, peak heart rate (HR), and HR recovery at 1- and 3-minutes will be recorded. VO2peak will be converted to age-, weight, and sex-specific norms and a %predicted value.

Trial Locations (1)

T6G 2B7

RECRUITING

University of Alberta, Edmonton

All Listed Sponsors
lead

University of Alberta

OTHER