153
Participants
Start Date
June 5, 2025
Primary Completion Date
December 31, 2028
Study Completion Date
December 31, 2028
Asparaginase Erwinia chrysanthemi
Given recombinant crisantaspase IM or crisantaspase IM or IV
Biospecimen Collection
Undergo collection of blood samples
Blinatumomab
Given IV
Bone Marrow Aspiration
Undergo bone marrow aspiration
Calaspargase Pegol
Given IV
Computed Tomography
Undergo CT
Cyclophosphamide
Given IV
Cytarabine
Given IT or IV
Daunorubicin
Given IV
Dexamethasone
Given PO or NG or IV
Doxorubicin
Given IV
Echocardiography Test
Undergo ECHO
FDG-Positron Emission Tomography
Undergo FDG-PET
Leucovorin
Given PO or NG or IV
Levoleucovorin
Given IV
Lumbar Puncture
Undergo lumbar puncture
Magnetic Resonance Imaging
Undergo MRI
Mercaptopurine
Given PO or NG
Methotrexate
Given IT or IV or PO or NG
Methylprednisolone
Given IV
Multigated Acquisition Scan
Undergo MUGA
Prednisolone
Given PO or NG
Prednisone
Given PO or NG
Therapeutic Hydrocortisone
Given IT
Thioguanine
Given PO or NG
Venetoclax
Given PO or NG
Vincristine
Given IV
RECRUITING
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
NYP/Weill Cornell Medical Center, New York
RECRUITING
Montefiore Medical Center - Moses Campus, The Bronx
RECRUITING
New York Medical College, Valhalla
RECRUITING
Albany Medical Center, Albany
RECRUITING
Roswell Park Cancer Institute, Buffalo
RECRUITING
University of Rochester, Rochester
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RECRUITING
Geisinger Medical Center, Danville
RECRUITING
Lehigh Valley Hospital-Cedar Crest, Allentown
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Alfred I duPont Hospital for Children, Wilmington
RECRUITING
Children's National Medical Center, Washington D.C.
RECRUITING
Sinai Hospital of Baltimore, Baltimore
RECRUITING
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
University of Virginia Cancer Center, Charlottesville
RECRUITING
Children's Hospital of The King's Daughters, Norfolk
RECRUITING
Wake Forest University Health Sciences, Winston-Salem
RECRUITING
East Carolina University, Greenville
RECRUITING
Carolinas Medical Center/Levine Cancer Institute, Charlotte
RECRUITING
Prisma Health Richland Hospital, Columbia
RECRUITING
BI-LO Charities Children's Cancer Center, Greenville
RECRUITING
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
RECRUITING
Nemours Children's Clinic-Jacksonville, Jacksonville
RECRUITING
University of Florida Health Science Center - Gainesville, Gainesville
RECRUITING
AdventHealth Orlando, Orlando
RECRUITING
Arnold Palmer Hospital for Children, Orlando
RECRUITING
Nemours Children's Hospital, Orlando
RECRUITING
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
RECRUITING
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
RECRUITING
The Children's Hospital at TriStar Centennial, Nashville
RECRUITING
Vanderbilt University/Ingram Cancer Center, Nashville
RECRUITING
East Tennessee Childrens Hospital, Knoxville
RECRUITING
Saint Jude Children's Research Hospital, Memphis
RECRUITING
University of Mississippi Medical Center, Jackson
RECRUITING
Norton Children's Hospital, Louisville
RECRUITING
University of Kentucky/Markey Cancer Center, Lexington
RECRUITING
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
RECRUITING
Rainbow Babies and Childrens Hospital, Cleveland
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Riley Hospital for Children, Indianapolis
RECRUITING
C S Mott Children's Hospital, Ann Arbor
RECRUITING
Bronson Methodist Hospital, Kalamazoo
RECRUITING
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
RECRUITING
Children's Hospital of Wisconsin, Milwaukee
RECRUITING
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
RECRUITING
University of Minnesota/Masonic Cancer Center, Minneapolis
RECRUITING
Lurie Children's Hospital-Chicago, Chicago
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Mercy Hospital Saint Louis, St Louis
RECRUITING
Children's Mercy Hospitals and Clinics, Kansas City
RECRUITING
Children's Hospital and Medical Center of Omaha, Omaha
RECRUITING
Children's Hospital New Orleans, New Orleans
RECRUITING
Ochsner Medical Center Jefferson, New Orleans
RECRUITING
Medical City Dallas Hospital, Dallas
RECRUITING
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
RECRUITING
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
RECRUITING
Children's Hospital of San Antonio, San Antonio
RECRUITING
Methodist Children's Hospital of South Texas, San Antonio
RECRUITING
Dell Children's Medical Center of Central Texas, Austin
RECRUITING
El Paso Children's Hospital, El Paso
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Saint Luke's Cancer Institute - Boise, Boise
RECRUITING
Loma Linda University Medical Center, Loma Linda
RECRUITING
Kaiser Permanente-Oakland, Oakland
RECRUITING
Seattle Children's Hospital, Seattle
RECRUITING
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
RECRUITING
Providence Alaska Medical Center, Anchorage
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Connecticut Children's Medical Center, Hartford
RECRUITING
Maine Children's Cancer Program, Scarborough
RECRUITING
UMass Memorial Medical Center - University Campus, Worcester
RECRUITING
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
RECRUITING
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
RECRUITING
Saint Joseph's Regional Medical Center, Paterson
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
RECRUITING
University Pediatric Hospital, San Juan
National Cancer Institute (NCI)
NIH