50
Participants
Start Date
March 1, 2024
Primary Completion Date
March 31, 2026
Study Completion Date
March 31, 2027
Avapritinib
50mg/m2/day for weighing bodyweight \>10kg, 1.65mg/kg/day for weighing ≤ 10kg, po, qd, d1-28.
Azacitidine Injection
75mg/m2/d for weighing \>10kg, 2.5mg/kg/d for weighing ≤ 10kg, d1-7, ivgtt, qd, more than 3 hours. Azacitidine and decitabine cannot be used simultaneously.
Decitabine Injection
20mg/m2/d for weighing \>10kg, 0.67mg/kg/d for weighing ≤ 10kg, d1-5, ivgtt, qd, more than 3 hours. Azacitidine and decitabine cannot be used simultaneously.
Idarubicin Hydrochloride
5mg/m2/day for weighing \>10kg, 0.17mg/kg/day for weighing ≤ 10kg, d 6, 8, 10 (d 8, 10, 12 for azacitidine) ivgtt, qod, more than 1 hour at 10 am.
Cytarabine
10mg/m2/day for weighing \>10kg, 0.33mg/kg/day for weighing ≤ 10kg, d6-15 （d8-17 for azacitidine ）, s.c., q12h.
Granulocyte Colony-Stimulating Factor
300ug/day for weighing \>10kg, 10ug/kg/day for weighing ≤10kg, d0-5, s.c., qd.
NOT_YET_RECRUITING
Children's Hospital Of Fudan University, Shanghai
RECRUITING
Children's Hospital of Soochow University, Suzhou
NOT_YET_RECRUITING
Xuzhou Children's Hospital, Xuzhou
NOT_YET_RECRUITING
First Affiliated Hospital Of University of Science and Technology of China, Hefei
NOT_YET_RECRUITING
The Second Hospital of Anhui Medical University, Hefei
NOT_YET_RECRUITING
Qilu Hospital of Shandong University, Jinan
NOT_YET_RECRUITING
Third Xiangya Hospital of Central South University, Changsha
NOT_YET_RECRUITING
XiangYa Hospital Central South University, Changsha
NOT_YET_RECRUITING
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
NOT_YET_RECRUITING
Kaifeng Children's Hospital, Kaifeng
NOT_YET_RECRUITING
Guangzhou Women and Children Medical Center, Guangzhou
NOT_YET_RECRUITING
The First Affiliated Hospital of Guangxi Medical University, Nanning
Children's Hospital of Soochow University
OTHER