Ticagrelor With Aspirin Dual Antiplatelet Therapy Combined With Intravenous Thrombolysis for Ischemic Stroke

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,380

Participants

Timeline

Start Date

April 3, 2024

Primary Completion Date

December 1, 2025

Study Completion Date

December 1, 2026

Conditions
Ischemic Stroke, Acute
Interventions
DRUG

Early Dual Antiplatelet Therapy

"Day 1(within 6.0 hours of onset, before or after intravenous thrombolysis) : Ticagrelor (180mg) + Aspirin (100mg), one dose;~Days 2-7: Ticagrelor (90mg/time, twice/day) + open-label Aspirin (100mg/time, once/day) ;~Days 8-90: open-label Aspirin (100mg/time, once/day)."

DRUG

Placebo

"Day 1(within 6.0 hours of onset, before or after intravenous thrombolysis) : Placebo of Ticagrelor (180mg) + Placebo of Aspirin (100mg), one dose;~Days 2-7: Placebo of Ticagrelor (90mg/time, twice/day) + open-label Aspirin (100mg/time, once/day) ;~Days 8-90: open-label Aspirin (100mg/time, once/day)."

Trial Locations (66)

Unknown

RECRUITING

Beijing Haidian Hospital, Beijing

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China Aerospace Science and Industry Corporation 731 Hospital, Beijing

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Chongqing Sanbo Changan Hospital, Chongqing

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The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou

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Heyuan People's Hospital, Heyuan

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Huazhou People's Hospital, Maoming

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Meizhou Hospital of Traditional Chinese Medicine, Meizhou

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Wuchuan People's Hospital, Zhanjiang

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The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai

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Yulin First People's Hospital, Yulin

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Qinghe County People's Hospital, Xingtai

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Harbin Medical University Affiliated First Hospital, Harbin

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Wuchang Hospital of Traditional Chinese Medicine, Harbin

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Puyang Anyang District Hospital, Anyang

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Jiyuan Hospital of Traditional Chinese Medicine, Jiyuan

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Kaifeng Central Hospital, Kaifeng

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Lankao County Central Hospital, Kaifeng

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Lankao County Traditional Chinese Medicine Hospital, Kaifeng

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Qixian People's Hospital, Kaifeng

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Qixian Traditional Chinese Medicine Hospital, Kaifeng

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The First People's Hospital of Xiangfu District, Kaifeng City, Kaifeng

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Luohe Third People's Hospital, Luohe

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Nanle Zhongxing Hospital, Puyang

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Shangqiu First People's Hospital, Shangqiu

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Shangqiu Third People's Hospital, Shangqiu

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Suixian Hospital of Traditional Chinese Medicine, Shangqiu

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Suixian People's Hospital, Shangqiu

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Xiayi People's Hospital, Shangqiu

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Yongcheng People's Hospital, Shangqiu

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Weishi County Central Hospital, Weishi Chengguanzhen

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Weishi County Traditional Chinese Medicine Hospital, Weishi Chengguanzhen

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The First Affiliated Hospital of Xinxiang Medical University, Xinxiang

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Jingmen Hospital of Traditional Chinese Medicine, Jingmen

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Wuhan Huangpi District People's Hospital, Wuhan

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Zhongnan Hospital of Wuhan University, Wuhan

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Liuyang Jili Hospital, Changsha

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Chenzhou First People's Hospital, Chenzhou

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The Fourth People's Hospital of Chenzhou City, Chenzhou

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The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou

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Tuquan People's Hospital, Hinggan

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Inner Mongolia Hangtian Hospital, Hohhot

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Zalantun People's Hospital, Hulunbuir

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Zalantun Zhongmeng Hospital, Hulunbuir

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Huaian Second People's Hospital, Huai'an

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Northern Jiangsu People's Hospital, Yangzhou

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Anshan Changda Hospital, Anshan

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Benxi Central Hospital, Benxi

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Dalian Lushunkou District People's Hospital, Dalian

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The First Affiliated Hospital of Dalian Medical University, Dalian

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Xinhua Hospital Affiliated to Dalian University, Dalian

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Dandong Central Hospital, Dandong

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Shenyang First People's Hospital, Shenyang

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Lingbao First People's Hospital, Henan

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Yantai Penglai Traditional Chinese Medicine Hospital, Dengzhou

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Guanxian People's Hospital, Liaocheng

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Linshu People's Hospital, Linyi

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Affiliated Hospital of Qingdao University, Qingdao

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Weihai Wendeng District People's Hospital, Weihai

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Zibo Municipal Hospital, Zibo

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Jincheng People's Hospital, Jincheng

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Yuci District People's Hospital, Jinzhong

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Linfen Central Hospital, Linfen

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Linfen People's Hospital, Linfen

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West China Hospital of Sichuan University, Chengdu

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Tianjin Xiqing Hospital, Tianjin

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The First Affiliated Hospital of Shihezi University Medical College, Shihezi

All Listed Sponsors
lead

Beijing Tiantan Hospital

OTHER