Prospective Assessment of Atherosclerotic Cardiovascular Disease (ASCVD) Risk

RecruitingOBSERVATIONAL
Enrollment

3,513

Participants

Timeline

Start Date

January 1, 2024

Primary Completion Date

October 31, 2024

Study Completion Date

December 31, 2024

Conditions
Atherosclerotic Cardiovascular Diseases (ASCVD)
Interventions
OTHER

Evaluating ASCVD risk over 10 and 30 year and lifetime

Utilizing validated tools such as the Pooled Cohort Equations (PCE) for 10-year ASCVD risk, the 30-year ASCVD risk prediction tool, and lifetime ASCVD risk categories, participants will undergo a thorough risk assessment. This multi-dimensional approach ensures a nuanced understanding of short and long-term cardiovascular risks. Further, The genetic risk for ApoB will be meticulously assessed by genotyping the APOB rs1042031 variant. Subsequently, the calculation of the genetic risk score (GRS) based on risk alleles will provide personalized insight into genetic predispositions related to ASCVD risk. Moreover, Participants will receive personalized management recommendations derived from the ACC/AHA Cardiovascular Risk Assessment Guidelines. These tailored suggestions may encompass dietary programs, lifestyle modifications, and, when indicated, pharmaceutical therapies like statins, aiming to mitigate identified risks effectively

Trial Locations (1)

75270

RECRUITING

Advanced Education Institute and Research Center, Karachi

All Listed Sponsors
collaborator

University of Karachi

OTHER

collaborator

Pakistan Cardiac Society (Heart House)

UNKNOWN

lead

Advanced Education & Research Center

OTHER