Electroacupuncture Plus Antiemetic Therapy for Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

370

Participants

Timeline

Start Date

March 7, 2024

Primary Completion Date

January 31, 2027

Study Completion Date

March 31, 2027

Conditions
ElectroacupunctureOlanzapine-contained Four-drug AntiemeticNausea and Vomiting
Interventions
DEVICE

Electroacupuncture

Participants in this arm will undergo electroacupuncture sessions once daily from day 1 to day 4. Electrical stimulation will be administered for 30 minutes at alternating frequencies of 2/10Hz

DRUG

Antiemetic Therapy

Participants will receive oral olanzapine at a dose of 5 mg per day on days 1 through 4, along with NK1 receptor antagonist, 5HT3 receptor antagonist, and intravenous dexamethasone at a dose of 10 mg 30 minutes prior to chemotherapy on Day 1, followed by intravenous dexamethasone at a dose of 8 mg on days 2, 3, and 4 post-chemotherapy.

DEVICE

Sham electroacupuncture

Participants assigned to this arm will receive sham electroacupuncture sessions daily from day 1 to day 4, mirroring the schedule of the experimental group

DRUG

Antiemetic Therapy

They will also receive the same antiemetic medications as the experimental group.

Trial Locations (1)

730000

RECRUITING

Second Hospital of Lanzhou University, Lanzhou

All Listed Sponsors
lead

Feixue Song

OTHER