Triple vs. Dual Adjuvant Therapy Following Liver Resection for HCC.

PHASE4RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

April 1, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2028

Conditions
HCC
Interventions
DRUG

HAIC plus PD-1 inhibitors plus lenvatinib

Patients in the triple adjuvant therapy group received one cycle of HAIC about a month after liver resection, HAIC was adopted the FOFOLX6 program (Folinic acid+5-fluorouracil+Oxaliplatin). The first cycle of PD-1 monoclonal antibody was administrated 2-4 weeks postoperatively, 200 mg IV, every 21 days for a total of 9 cycles. Lenvatinib was initiated orally 2-4 weeks postoperatively for 6 months.

DRUG

PD-1 inhibitors plus lenvatinib

The first cycle of PD-1 monoclonal antibody was administrated 2-4 weeks postoperatively, 200 mg IV, every 21 days for a total of 9 cycles. Lenvatinib was initiated orally 2-4 weeks postoperatively for 6 months.

Trial Locations (1)

430000

RECRUITING

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Wuhan

All Listed Sponsors
lead

Chen Xiaoping

OTHER