A Non-interventional Study for Women With HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer to Evaluate the Real-world Effectiveness of Treatment Algorithms Beginning With Ribociclib + AI/FUL, or With Endocrine Therapy or Chemotherapy as First Line Treatment

CompletedOBSERVATIONAL
Enrollment

2,615

Participants

Timeline

Start Date

October 9, 2017

Primary Completion Date

February 16, 2025

Study Completion Date

February 16, 2025

Conditions
Breast Cancer
Interventions
DRUG

First-line Ribociclib + endocrine therapy

Ribociclib + letrozole, or Ribociclib + anastrazole, or Ribociclib + exemestane, or Ribociclib + fulvestrant

DRUG

First-line endocrine therapy

As of physicians choice

DRUG

First-line chemtherapy

As of physicians choice

Trial Locations (265)

10117

Novartis Investigative Site, Berlin

10317

Novartis Investigative Site, Berlin

10715

Novartis Investigative Site, Berlin

12487

Novartis Investigative Site, Berlin

13187

Novartis Investigative Site, Berlin

13353

Novartis Investigative Site, Berlin

13581

Novartis Investigative Site, Berlin

14169

Novartis Investigative Site, Berlin

14197

Novartis Investigative Site, Berlin

14467

Novartis Investigative Site, Potsdam

14770

Novartis Investigative Site, Brandenburg

Novartis Investigative Site, Brandenburg

14974

Novartis Investigative Site, Ludwigsfelde

15517

Novartis Investigative Site, Fürstenwalde

16816

Novartis Investigative Site, Neuruppin

17036

Novartis Investigative Site, Neu-Brandenburg

17475

Novartis Investigative Site, Greifswald

18057

Novartis Investigative Site, Rostock

Novartis Investigative Site, Rostock

18059

Novartis Investigative Site, Rostock

18435

Novartis Investigative Site, Stralsund

19059

Novartis Investigative Site, Schwerin

20259

Novartis Investigative Site, Hamburg

20357

Novartis Investigative Site, Hamburg

21244

Novartis Investigative Site, Buchholz in der Nordheide

21680

Novartis Investigative Site, Stade

22081

Novartis Investigative Site, Hamburg

22087

Novartis Investigative Site, Hamburg

22291

Novartis Investigative Site, Hamburg

22457

Novartis Investigative Site, Hamburg

23538

Novartis Investigative Site, Lübeck

23563

Novartis Investigative Site, Lübeck

23701

Novartis Investigative Site, Eutin

24105

Novartis Investigative Site, Kiel

24939

Novartis Investigative Site, Flensburg

26121

Novartis Investigative Site, Oldenburg

26389

Novartis Investigative Site, Wilhelmshaven

26655

Novartis Investigative Site, Westerstede

27239

Novartis Investigative Site, Twistringen

27356

Novartis Investigative Site, Rotenburg (Wümme)

27574

Novartis Investigative Site, Bremerhaven

27576

Novartis Investigative Site, Bremerhaven

28205

Novartis Investigative Site, Bremen

28209

Novartis Investigative Site, Bremen

28239

Novartis Investigative Site, Bremen

29223

Novartis Investigative Site, Celle

30161

Novartis Investigative Site, Hanover

30171

Novartis Investigative Site, Hanover

30177

Novartis Investigative Site, Hanover

30625

Novartis Investigative Site, Hanover

31134

Novartis Investigative Site, Hildesheim

31241

Novartis Investigative Site, Ilsede

31785

Novartis Investigative Site, Hamelin

Novartis Investigative Site, Hamelin

32429

Novartis Investigative Site, Minden

32657

Novartis Investigative Site, Lemgo

33098

Novartis Investigative Site, Paderborn

33611

Novartis Investigative Site, Bielefeld

33615

Novartis Investigative Site, Bielefeld

34119

Novartis Investigative Site, Kassel

35037

Novartis Investigative Site, Marburg

35043

Novartis Investigative Site, Marburg

35423

Novartis Investigative Site, Lich

35578

Novartis Investigative Site, Wetzlar

37073

Novartis Investigative Site, Göttingen

37075

Novartis Investigative Site, Göttingen

38100

Novartis Investigative Site, Braunschweig

38226

Novartis Investigative Site, Salzgitter

38304

Novartis Investigative Site, Wolfenbüttel

38440

Novartis Investigative Site, Wolfsburg

38642

Novartis Investigative Site, Goslar

38820

Novartis Investigative Site, Halberstadt

39108

Novartis Investigative Site, Magdeburg

39130

Novartis Investigative Site, Magdeburg

39576

Novartis Investigative Site, Stendal

40325

Novartis Investigative Site, Düsseldorf

40625

Novartis Investigative Site, Düsseldorf

40724

Novartis Investigative Site, Hilden

41061

Novartis Investigative Site, Mönchengladbach

41462

Novartis Investigative Site, Neuss

41464

Novartis Investigative Site, Neuss

42551

Novartis Investigative Site, Velbert

42853

Novartis Investigative Site, Remscheid

42859

Novartis Investigative Site, Remscheid Innen

44137

Novartis Investigative Site, Dortmund

44309

Novartis Investigative Site, Dortmund

44649

Novartis Investigative Site, Herne

44787

Novartis Investigative Site, Bochum

44791

Novartis Investigative Site, Bochum

45147

Novartis Investigative Site, Essen

45879

Novartis Investigative Site, Gelsenkirchen

46236

Novartis Investigative Site, Bottrop

46483

Novartis Investigative Site, Wesel

46485

Novartis Investigative Site, Wesel

47441

Novartis Investigative Site, Moers

47574

Novartis Investigative Site, Goch

47805

Novartis Investigative Site, Krefeld

48145

Novartis Investigative Site, Münster

48431

Novartis Investigative Site, Rheine

49076

Novartis Investigative Site, Osnabrück

Novartis Investigative Site, Osnabrück

49124

Novartis Investigative Site, Georgsmarienhütte

49377

Novartis Investigative Site, Vechta

49401

Novartis Investigative Site, Damme

49808

Novartis Investigative Site, Lingen Ems

50179

Novartis Investigative Site, Cologne

50671

Novartis Investigative Site, Cologne

50935

Novartis Investigative Site, Cologne

50937

Novartis Investigative Site, Cologne

51067

Novartis Investigative Site, Cologne

51465

Novartis Investigative Site, Bergisch Gladbach

51643

Novartis Investigative Site, Gummersbach

52146

Novartis Investigative Site, Würselen

52222

Novartis Investigative Site, Stolberg

53111

Novartis Investigative Site, Bonn

53113

Novartis Investigative Site, Bonn

Novartis Investigative Site, Bonn

53177

Novartis Investigative Site, Bonn

53840

Novartis Investigative Site, Troisdorf

54290

Novartis Investigative Site, Trier

55131

Novartis Investigative Site, Mainz

55469

Novartis Investigative Site, Simmern

56068

Novartis Investigative Site, Koblenz

56727

Novartis Investigative Site, Mayen

57072

Novartis Investigative Site, Siegen

57462

Novartis Investigative Site, Olpe

58095

Novartis Investigative Site, Hagen

58239

Novartis Investigative Site, Schwerte

58313

Novartis Investigative Site, Herdecke

58455

Novartis Investigative Site, Witten

59494

Novartis Investigative Site, Soest

59759

Novartis Investigative Site, Arnsberg

60398

Novartis Investigative Site, Frankfurt am Main

60431

Novartis Investigative Site, Frankfurt am Main

61231

Novartis Investigative Site, Bad Nauheim

61352

Novartis Investigative Site, Bad Homburg

63069

Novartis Investigative Site, Offenbach

63110

Novartis Investigative Site, Rodgau

63225

Novartis Investigative Site, Langen

63450

Novartis Investigative Site, Hanau

63739

Novartis Investigative Site, Aschaffenburg

64283

Novartis Investigative Site, Darmstadt

64711

Novartis Investigative Site, Erbach im Odenwald

65189

Novartis Investigative Site, Wiesbaden

65191

Novartis Investigative Site, Wiesbaden

65428

Novartis Investigative Site, Rüsselsheim am Main

65929

Novartis Investigative Site, Frankfurt am Main

66113

Novartis Investigative Site, Saarbrücken

66333

Novartis Investigative Site, Völklingen

66421

Novartis Investigative Site, Homburg

66740

Novartis Investigative Site, Saarlouis

66822

Novartis Investigative Site, Lebach

67434

Novartis Investigative Site, Neustadt

67550

Novartis Investigative Site, Worms

67655

Novartis Investigative Site, Kaiserslautern

68161

Novartis Investigative Site, Mannheim

68165

Novartis Investigative Site, Mannheim

68167

Novartis Investigative Site, Mannheim

69469

Novartis Investigative Site, Weinheim

70174

Novartis Investigative Site, Stuttgart

70199

Novartis Investigative Site, Stuttgart

71032

Novartis Investigative Site, Böblingen

71364

Novartis Investigative Site, Winnenden

72076

Novartis Investigative Site, Tübingen

72250

Novartis Investigative Site, Freudenstadt

72488

Novartis Investigative Site, Sigmaringen

72622

Novartis Investigative Site, Nürtingen

72764

Novartis Investigative Site, Reutlingen

73557

Novartis Investigative Site, Mutlangen

73614

Novartis Investigative Site, Schorndorf

73730

Novartis Investigative Site, Esslingen am Neckar

73760

Novartis Investigative Site, Ostfildern

74523

Novartis Investigative Site, Schwaebisch

Novartis Investigative Site, Schwäbisch Hall

75175

Novartis Investigative Site, Pforzheim

76133

Novartis Investigative Site, Karlsruhe

76135

Novartis Investigative Site, Karlsruhe

76199

Novartis Investigative Site, Karlsruhe

76532

Novartis Investigative Site, Baden-Baden

77654

Novartis Investigative Site, Offenburg

78628

Novartis Investigative Site, Rottweil

79106

Novartis Investigative Site, Freiburg im Breisgau

79539

Novartis Investigative Site, Loerrach

80639

Novartis Investigative Site, Munich

81241

Novartis Investigative Site, Munich

81925

Novartis Investigative Site, Munich

83022

Novartis Investigative Site, Rosenheim

84036

Novartis Investigative Site, Landshut

84307

Novartis Investigative Site, Eggenfelden

84503

Novartis Investigative Site, Altötting

Novartis Investigative Site, Altötting

85560

Novartis Investigative Site, Ebersberg

86150

Novartis Investigative Site, Augsburg

86152

Novartis Investigative Site, Augsburg

86179

Novartis Investigative Site, Augsburg

86316

Novartis Investigative Site, Friedberg

86381

Novartis Investigative Site, Krumbach

86609

Novartis Investigative Site, Donauwörth

87439

Novartis Investigative Site, Kempten

87700

Novartis Investigative Site, Memmingen

88045

Novartis Investigative Site, Friedrichshafen

88214

Novartis Investigative Site, Ravensburg

89073

Novartis Investigative Site, Ulm

89081

Novartis Investigative Site, Ulm

89522

Novartis Investigative Site, Heidenheim

90409

Novartis Investigative Site, Nuremberg

90419

Novartis Investigative Site, Nuremberg

90449

Novartis Investigative Site, Nuremberg

91054

Novartis Investigative Site, Erlangen

91522

Novartis Investigative Site, Ansbach

92224

Novartis Investigative Site, Amberg

92637

Novartis Investigative Site, Weiden

93053

Novartis Investigative Site, Regensburg

Novartis Investigative Site, Regensburg

94036

Novartis Investigative Site, Passau

94315

Novartis Investigative Site, Straubing

95028

Novartis Investigative Site, Hof

95326

Novartis Investigative Site, Kulmbach

95445

Novartis Investigative Site, Bayreuth

Novartis Investigative Site, Bayreuth

95615

Novartis Investigative Site, Marktredwitz

96049

Novartis Investigative Site, Bamberg

96052

Novartis Investigative Site, Bamberg

96317

Novartis Investigative Site, Kronach

97070

Novartis Investigative Site, Würzburg

97080

Novartis Investigative Site, Würzburg

97422

Novartis Investigative Site, Schweinfurt

98527

Novartis Investigative Site, Suhl

Novartis Investigative Site, Suhl

98617

Novartis Investigative Site, Meiningen

99084

Novartis Investigative Site, Erfurt

Novartis Investigative Site, Erfurt

99510

Novartis Investigative Site, Apolda

99734

Novartis Investigative Site, Nordhausen

99817

Novartis Investigative Site, Eisenach

99974

Novartis Investigative Site, Mühlhausen

03048

Novartis Investigative Site, Cottbus

03253

Novartis Investigative Site, Doberlug-Kirchhain

03130

Novartis Investigative Site, Spremberg

06484

Novartis Investigative Site, Quedlinburg

01127

Novartis Investigative Site, Dresden

01307

Novartis Investigative Site, Dresden

Novartis Investigative Site, Dresden

04103

Novartis Investigative Site, Leipzig

02999

Novartis Investigative Site, Lohsa-Weisskollm

01796

Novartis Investigative Site, Pirna

08228

Novartis Investigative Site, Rodewisch

09481

Novartis Investigative Site, Scheibenberg

04435

Novartis Investigative Site, Schkeuditz

Novartis Investigative Site, Schkeuditz

02763

Novartis Investigative Site, Zittau

08060

Novartis Investigative Site, Zxickau

06110

Novartis Investigative Site, Halle

04924

Novartis Investigative Site, Bad Liebenwerda

09113

Novartis Investigative Site, Chemnitz

09117

Novartis Investigative Site, Chemnitz

06847

Novartis Investigative Site, Dessau

07548

Novartis Investigative Site, Gera

07740

Novartis Investigative Site, Jena

04129

Novartis Investigative Site, Leipzig

04277

Novartis Investigative Site, Leipzig

04683

Novartis Investigative Site, Naunhof

01844

Novartis Investigative Site, Neustadt Sachsen

08525

Novartis Investigative Site, Plauen Kauschwitz

04860

Novartis Investigative Site, Torgau

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY