Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection

NANot yet recruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

January 1, 2026

Primary Completion Date

June 30, 2027

Study Completion Date

December 30, 2027

Conditions
Nosocomial InfectionNosocomial PneumoniaTracheobronchitisMechanical Ventilation ComplicationEndotracheal Intubation
Interventions
DEVICE

Mechanical insufflation-exsufflation

Combined use of mechanical insufflation-exsufflation with nebulized hypertonic saline in intubated patients with nosocomial respiratory tract infection

OTHER

Standard of Care

systemic antibiotic therapy and catheter suctioning of secretions as recommended by guidelines

OTHER

Hypertonic saline with hyaluronic acid

Commercially available combination of 7% hypertonic saline with 0.1% hyaluronic acid given as nebulization during the MI-E session

Trial Locations (8)

28040

Hospital Clinico San Carlos, Madrid

Hospital Clínico San Carlos, Madrid

Unknown

Hospital Vall d´Hebrón., Barcelona

Hospital Nuestra Señora de la Candelaria., Santa Cruz de Tenerife

Hospital de la Princesa, Madrid

Hospital Doce de Octubre, Madrid

Hospital Álvaro Cunqueiro., Vigo

Virgen de la Salud, Toledo

All Listed Sponsors
collaborator

FUNDACION PARA LA INVESTIGACION HOSPITAL CLINICO SAN CARLOS

OTHER

lead

Hospital San Carlos, Madrid

OTHER

NCT06310941 - Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection | Biotech Hunter | Biotech Hunter