NCT06307015View on ClinicalTrials.gov

De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE)

NARecruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2031

Conditions
HPV Positive Oropharyngeal Squamous Cell Carcinoma
Interventions
RADIATION

De-escalation

Surgical resection of primary oropharyngeal tumour followed by de-escalated radiation therapy (30Gy) with concurrent platinum-based chemotherapy to oropharynx + neck, followed by surgical neck dissection

RADIATION

Standard of care

Radiation therapy (70Gy) with concurrent platinum-based chemotherapy to oropharynx + neck

Trial Locations (1)

2065

RECRUITING

Northern Sydney Cancer Centre, Royal North Shore Hospital, Saint Leonards

All Listed Sponsors
lead

Royal North Shore Hospital

OTHER