CytoREductive prostAtectomy for Poly-metastatic Hormone sensiTIVE Prostate Cancer

Under continuous ADT, docetaxel 75mg/m\^2 body surface area every 21 days, oral dexamethasone 7.5mg pretreatment 12h, 3h, 1h before each infusion of docetaxel, and a total of 10mg of prednisolone per day when needed according to the decision of the researcher (in the case of grade 3 and above neutropenia or peripheral edema); oral darolutamide 600mg twice per day, 21 days for one cycle, six cycles in total.

Under continuous ADT, oral darolutamide 600mg twice per day

Cytoreductive prostatectomy was performed after six cycles of neoadjuvant systemic chemohormonal therapy.

Postoperative adjuvant radiotherapy of prostate bed is performed, if margin positive, with conventional segmentation and the dose of 64-72Gy.