Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)

PHASE3RecruitingINTERVENTIONAL
Enrollment

520

Participants

Timeline

Start Date

June 11, 2024

Primary Completion Date

September 12, 2028

Study Completion Date

June 14, 2030

Conditions
Non-small Cell Lung Cancer (NSCLC)
Interventions
BIOLOGICAL

Sacituzumab tirumotecan

4 mg/kg via IV infusion

DRUG

Pemetrexed

500 mg/m\^2 via IV infusion

DRUG

Carboplatin

AUC 5 mg/mL\*min via IV infusion

DRUG

H1 Receptor Antagonist

Administered as rescue medication per approved product label

DRUG

H2 Receptor Antagonist

Administered as rescue medication per approved product label

DRUG

Acetaminophen (or equivalent)

Administered as rescue medication per approved product label

DRUG

Dexamethasone (or equivalent)

Administered as rescue medication per approved product label

DRUG

Steroid Mouthwash (dexamethasone or equivalent)

Administered as rescue medication per approved product label

Trial Locations (155)

106

RECRUITING

National Taiwan University Cancer Center (NTUCC) ( Site 3907), Taipei City

220

RECRUITING

Far Eastern Memorial Hospital ( Site 3912), New Taipei City

300

RECRUITING

National Taiwan University Hospital - Hsinchu branch ( Site 3900), Hsinchu

333

RECRUITING

Chang Gung Medical Foundation-Linkou Branch-Clinic of Chest Medicine ( Site 3911), Taoyuan District

704

RECRUITING

National Cheng Kung University Hospital ( Site 3901), Tainan City

10002

RECRUITING

National Taiwan University Hospital-Oncology ( Site 3908), Taipei

10300

RECRUITING

Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 4006), Dusit

10400

RECRUITING

Ramathibodi Hospital ( Site 4001), Ratchathewi

10408

RECRUITING

National Cancer Center ( Site 3803), Goyang-si

10449

RECRUITING

Mackay Memorial Hospital-Chest Medicine ( Site 3902), Taipei

10450

RECRUITING

Hospital Pulau Pinang-Oncology, radiotherapy and palliat ( Site 3501), George Town

10700

RECRUITING

Faculty of Medicine Siriraj Hospital ( Site 4004), Bangkok

11794

RECRUITING

Stony Brook University-Cancer Center ( Site 0038), Stony Brook

13009

RECRUITING

Clinique Clairval ( Site 1306), Marseille

13620

RECRUITING

Seoul National University Bundang Hospital ( Site 3807), Seongnam

15706

RECRUITING

CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2322), Santiago de Compostela

16247

RECRUITING

The Catholic University Of Korea St. Vincent's Hospital ( Site 3800), Suwon

16499

RECRUITING

Ajou University Hospital ( Site 3813), Suwon

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1800), Milan

20141

RECRUITING

Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 1803), Milan

21005

RECRUITING

Hospital Universitario Juan Ramon Jimenez-Oncología Medica ( Site 2323), Huelva

25100

RECRUITING

Hospital Tengku Ampuan Afzan ( Site 3506), Kuantan

28644

RECRUITING

Chungbuk National University Hospital ( Site 3804), Cheongju-si

30060

COMPLETED

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0003), Marietta

32763

RECRUITING

Mid Florida Hematology and Oncology Center ( Site 0005), Orange City

35015

RECRUITING

Chungnam national university hospital ( Site 3806), Junggu

35575

RECRUITING

I.E.U. Medical Point Hastanesi-Oncology ( Site 2503), Izmir

40002

RECRUITING

Faculty of Medicine - Khon Kaen University ( Site 4002), Muang

40705

RECRUITING

Taichung Veterans General Hospital-Chest ( Site 3910), Taichung

41009

RECRUITING

Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2324), Seville

42601

RECRUITING

Keimyung University Dongsan Hospital CRC room 1 ( Site 3814), Daegu

44630

RECRUITING

CIO - Centro de Inmuno-Oncología de Occidente ( Site 0700), Guadalajara

48109

RECRUITING

University of Michigan ( Site 0009), Ann Arbor

49241

RECRUITING

Pusan National University Hospital ( Site 3805), Busan

50006

RECRUITING

Changhua Christian Hospital ( Site 3904), Changhua

50134

RECRUITING

Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 1804), Florence

50200

RECRUITING

Maharaj Nakorn Chiang Mai Hospital ( Site 4005), Muang

50612

RECRUITING

Pusan National University Yangsan Hospital ( Site 3802), Pusan

52000

RECRUITING

Lampang Cancer Hospital ( Site 4000), Lampang

57104

RECRUITING

Sanford Cancer Center ( Site 0024), Sioux Falls

58122

RECRUITING

Sanford Fargo Medical Center ( Site 0028), Fargo

59100

RECRUITING

University Malaya Medical Centre ( Site 3507), Lembah Pantai

62250

RECRUITING

National Cancer Institute-Radiotherapy and Oncology ( Site 3504), Putrajaya

64460

RECRUITING

"Hospital Universitario Dr. Jose Eleuterio Gonzalez-Servicio de Oncología ( Site 0705)", Monterrey

65807

RECRUITING

Cox Medical Center North - Cox Medical Center/ Hematology/Medical Oncology ( Site 0051), Springfield

67091

RECRUITING

Nouvel Hôpital Civil (NHC) ( Site 1302), Strasbourg

68000

RECRUITING

Oaxaca Site Management Organization S.C. ( Site 0701), Oaxaca City

68020

RECRUITING

Centro de Investigacion Clinica de Oaxaca ( Site 0704), Oaxaca City

70124

RECRUITING

Instituto Tumori Giovanni Paolo II-SSD Oncologia Medica per la Patologia Toracica ( Site 1802), Bari

73657

RECRUITING

Chi Mei Hospital - Liouying Branch ( Site 3909), Tainan City

75014

RECRUITING

Hopitaux Universitaires Paris Centre-Hopital Cochin-Unité d'Oncologie Thoracique ( Site 1304), Paris

77030

RECRUITING

University of Texas MD Anderson ( Site 0063), Houston

77090

COMPLETED

Millennium Research & Clinical Development ( Site 0035), Houston

83301

RECRUITING

Chang Gung Memorial Hospital at Kaohsiung ( Site 3905), Kaohsiung City

90110

RECRUITING

Songklanagarind hospital ( Site 4003), Hat Yai

93586

RECRUITING

Sarawak General Hospital-Radiotherapy Unit ( Site 3508), Kuching

94115

RECRUITING

Kaiser Permanente - San Francisco ( Site 0056), San Francisco

94589

RECRUITING

Kaiser Permanente-Kaiser Permanente ( Site 0036), Vallejo

94596

RECRUITING

Kaiser Permanente - Walnut Creek ( Site 0058), Walnut Creek

94611

RECRUITING

Kaiser Permanente - Oakland ( Site 0054), Oakland

94805

RECRUITING

Gustave Roussy ( Site 1303), Villejuif

95051

RECRUITING

Kaiser Permanente - Santa Clara ( Site 0057), Santa Clara

95661

RECRUITING

Kaiser Permanente - Roseville ( Site 0055), Roseville

100000

RECRUITING

Hanoi Oncology Hospital ( Site 4198), Hanoi

RECRUITING

K Hospital - National Cancer Hospital ( Site 4193), Hanoi

RECRUITING

National Lung Hospital-Oncology Department ( Site 4194), Hanoi

100142

RECRUITING

Beijing Cancer hospital ( Site 3100), Beijing

100730

RECRUITING

Beijing Peking Union Medical College Hospital-pneumology department ( Site 3107), Beijing

110029

RECRUITING

All India Institute of Medical Sciences-Department of medical oncology ( Site 3303), New Delhi

110076

RECRUITING

Indraprastha Apollo Hospitals-APOLLO RESEARCH INNOVATION ( Site 3301), New Delhi

110085

ACTIVE_NOT_RECRUITING

Rajiv Gandhi Cancer Institute And Research Centre ( Site 3300), New Delhi

110131

RECRUITING

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0600), Bogotá

110301

RECRUITING

Taipei Medical University Hospital ( Site 3903), Taipei

111321

RECRUITING

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0606), Bogotá

122001

RECRUITING

Artemis hospital ( Site 3307), Gurugram

150081

RECRUITING

Harbin Medical University Cancer Hospital ( Site 3109), Harbin

200002

RECRUITING

Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0601), Valledupar

200032

RECRUITING

Zhongshan Hospital of Fudan University ( Site 3133), Shanghai

210031

RECRUITING

Nanjing Drum Tower Hospital JiangBei International Branch Hospital ( Site 3117), Nanjing

215006

COMPLETED

The First Affiliated Hospital of Soochow University-Respiratory Department ( Site 3118), Suzhou

230002

RECRUITING

IMAT S.A.S ( Site 0602), Montería

230031

RECRUITING

Anhui Provincial Cancer Hospital ( Site 3132), Hefei

250013

RECRUITING

Jinan Central Hospital ( Site 3113), Jinan

250117

RECRUITING

Shandong Cancer Hospital ( Site 3112), Jinan

310003

RECRUITING

The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3101), Hangzhou

310016

RECRUITING

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-Medical Oncology ( Site 3106), Hangzhou

325015

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University-Respiratory department ( Site 3120), Wenzhou

330006

COMPLETED

The Second Affiliated Hospital of Nanchang University ( Site 3119), Nanchang

350014

RECRUITING

Fujian Cancer Hospital ( Site 3124), Fuzhou

361003

RECRUITING

The First Affiliated hospital of Xiamen University ( Site 3125), Xiamen

400012

RECRUITING

Tata Memorial Hospital-Medical Oncology ( Site 3304), Mumbai

400030

RECRUITING

Chongqing University Cancer Hospital-Medical Oncology ( Site 3128), Chongqing

400053

RECRUITING

Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute-Centre for cancer ( Site 3302), Mumbai

410011

RECRUITING

The Second Xiangya Hospital of Central South University-Oncology ( Site 3104), Changsha

410013

RECRUITING

Shanxi Cancer Hospital ( Site 3114), Taiyuan

430000

RECRUITING

Tongji Hospital Tongji Medical,Science & Technology ( Site 3121), Wuhan

430079

RECRUITING

Hubei Cancer Hospital ( Site 3122), Wuhan

450008

RECRUITING

Henan Cancer Hospital ( Site 3105), Zhengzhou

510515

RECRUITING

Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 3102), Guangzhou

530021

RECRUITING

Guangxi Medical University Affiliated Tumor Hospital-Respiratory Oncology ( Site 3103), Nanning

610041

RECRUITING

West China Hospital, Sichuan University ( Site 3126), Chengdu

610042

RECRUITING

Sichuan Cancer hospital. ( Site 3127), Chengdu

660001

RECRUITING

Oncologos del Occidente ( Site 0604), Pereira

700000

RECRUITING

Oncology Hospital ( Site 4191), Ho Chi Minh City

RECRUITING

Thong Nhat Hospital ( Site 4192), Tan Binh District

RECRUITING

Cho Ray Hospital ( Site 4190), Ho Chi Minh City

RECRUITING

Tam Anh TP.HCM General Hospital ( Site 4196), Ho Chi Minh City

710004

RECRUITING

The Second Affiliated Hospital of Xi'an Jiaotong University ( Site 3130), Xi'an

760032

RECRUITING

Fundacion Valle del Lili- CIC-Oncology CIC ( Site 0605), Santiago de Cali

08816

RECRUITING

Astera Cancer Care ( Site 0032), East Brunswick

C1430EGF

RECRUITING

Clinica Adventista Belgrano-Oncology ( Site 0315), Caba.

C1426ANZ

RECRUITING

Instituto Alexander Fleming ( Site 0307), Ciudad Autónoma de Buenos Aires

C1280AEB

RECRUITING

Hospital Británico de Buenos Aires-Oncology ( Site 0304), Buenos Aires

X5800ALB

RECRUITING

Centro Privado de RMI Río Cuarto S.A. II ( Site 0310), Río Cuarto

S2000KZE

RECRUITING

Instituto de Oncología de Rosario ( Site 0301), Rosario

F5300COE

RECRUITING

Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0303), La Rioja

T6G 1Z2

RECRUITING

Cross Cancer Institute ( Site 0201), Edmonton

N2G 1G3

RECRUITING

Waterloo Regional Health Network (WRHN) ( Site 0207), Kitchener

M5G 2M9

RECRUITING

Princess Margaret Cancer Centre ( Site 0203), Toronto

H4A 3J1

RECRUITING

McGill University Health Centre ( Site 0204), Montreal

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1801), Roma

470-1192

RECRUITING

Fujita Health University Hospital ( Site 3409), Toyoake

791-0295

RECRUITING

Ehime University Hospital ( Site 3411), Tōon

811-1395

RECRUITING

National Hospital Organization Kyushu Cancer Center ( Site 3401), Fukuoka

373-8550

RECRUITING

Gunma Prefectural Cancer Center ( Site 3413), Ōta

920-8641

RECRUITING

Kanazawa University Hospital ( Site 3402), Kanazawa

216-8511

RECRUITING

St. Marianna University Hospital ( Site 3415), Kawasaki

241-8515

RECRUITING

Kanagawa Cancer Center ( Site 3416), Yokohama

981-1293

RECRUITING

Miyagi Cancer Center ( Site 3406), Natori-shi

573-1191

RECRUITING

Kansai Medical University Hospital ( Site 3414), Hirakata

362-0806

RECRUITING

Saitama Prefectural Cancer Center ( Site 3417), Kitaadachi-gun

411-8777

RECRUITING

Shizuoka Cancer Center ( Site 3405), Sunto-gun

104-0045

RECRUITING

National Cancer Center Hospital ( Site 3408), Chūō

143-8541

RECRUITING

Toho University Omori Medical Center ( Site 3407), Ōta-ku

812-8582

RECRUITING

Kyushu University Hospital ( Site 3400), Fukuoka

730-8518

RECRUITING

Hiroshima City Hiroshima Citizens Hospital ( Site 3419), Hiroshima

951-8566

RECRUITING

Niigata Cancer Center Hospital ( Site 3403), Niigata

700-8558

RECRUITING

Okayama University Hospital ( Site 3404), Okayama

541-8567

RECRUITING

Osaka International Cancer Institute ( Site 3410), Osaka

545-0051

RECRUITING

Osaka Metropolitan University Hospital ( Site 3412), Osaka

06700

RECRUITING

Arké SMO S.A. de C.V. ( Site 0706), Mexico City

85-796

RECRUITING

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2003), Bydgoszcz

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2000), Warsaw

15-027

RECRUITING

Bialostockie Centrum Onkologii ( Site 2010), Bialystok

44-102

RECRUITING

Narodowy Instytut Onkologii - Oddzial w Gliwicach-II Klinika Radioterapi i Chemioterapii ( Site 2002), Gliwice

03312

RECRUITING

The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3812), Seoul

05505

RECRUITING

Asan Medical Center ( Site 3810), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 3811), Seoul

08308

RECRUITING

Korea University Guro Hospital ( Site 3808), Seoul

08908

RECRUITING

Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2321), LHospitalet de Llobregat

171 64

RECRUITING

Karolinska Universitetssjukhuset Solna ( Site 2401), Stockholm

01140

RECRUITING

Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2504), Adana

06230

RECRUITING

Hacettepe Universite Hastaneleri-oncology hospital ( Site 2501), Ankara

06520

RECRUITING

Memorial Ankara Hastanesi-Medical Oncology ( Site 2505), Ankara

06800

RECRUITING

Ankara Bilkent Şehir Hastanesi ( Site 2500), Ankara

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