Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and PCSK9 Inhibitor for pMMR/MSS Locally Advanced Mid-low Rectal Cancer

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

April 30, 2024

Primary Completion Date

April 30, 2026

Study Completion Date

May 31, 2026

Conditions
Locally Advanced Rectal Cancer
Interventions
COMBINATION_PRODUCT

Long-course chemoradiation and PD-1 inhibitor, with PCSK9 inhibitor

In long-course chemoradiotherapy (CRT) + PD-1 inhibitor for LARC patients, the experimental group used concurrent PCSK9 inhibitor, and the active comparison group did not use PCSK9 inhibitor.

COMBINATION_PRODUCT

Long-course chemoradiation and PD-1 inhibitor, without PCSK9 inhibitor

In long-course chemoradiotherapy (CRT) + PD-1 inhibitor for LARC patients, the experimental group used concurrent PCSK9 inhibitor, and the active comparison group did not use PCSK9 inhibitor.

Trial Locations (2)

100050

Beijing Friendship Hospital, Capital Medical University, Beijing

Beijing Friendship Hospital, Beijing

All Listed Sponsors
collaborator

Peking Union Medical College Hospital

OTHER

collaborator

Peking University Cancer Hospital & Institute

OTHER

collaborator

Changhai Hospital

OTHER

lead

Beijing Friendship Hospital

OTHER

NCT06304987 - Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and PCSK9 Inhibitor for pMMR/MSS Locally Advanced Mid-low Rectal Cancer | Biotech Hunter | Biotech Hunter