NCT06303128View on ClinicalTrials.gov

Penicillin Allergy Delabeling After a One-Dose Versus Two-Dose Graded Direct Oral Challenge

PHASE3RecruitingINTERVENTIONAL
Enrollment

380

Participants

Timeline

Start Date

February 3, 2024

Primary Completion Date

July 31, 2026

Study Completion Date

December 31, 2026

Conditions
Penicillin Allergy
Interventions
DRUG

Amoxicillin 250 MG

Liquid amoxicillin 250mg PO

DRUG

Placebo

Given prior to amoxicillin 250mg in one-dose group

DRUG

Amoxicillin 62.5mg

Given first in two-dose group, liquid amoxicillin 62.5mg PO

DRUG

Amoxicillin 187.5mg

Given second in two-dose group, liquid amoxicillin 187.5mg PO

Trial Locations (1)

79430

RECRUITING

Texas Tech University Health Sciences Center, Lubbock

All Listed Sponsors
collaborator

Texas Tech University Health Sciences Center

OTHER

lead

James Tarbox, MD

OTHER