A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

1,005

Participants

Timeline

Start Date

March 13, 2024

Primary Completion Date

May 13, 2026

Study Completion Date

November 4, 2026

Conditions
Obesity
Interventions
DRUG

Trevogrumab-Part A

Administered IV or SC in Part A

DRUG

Trevogrumab-Part B and Part C

Administered SC in Part B, Part C

DRUG

Garetosmab

Administered IV in Part B

DRUG

Semaglutide

Administered SC in Part B and Part C

DRUG

Matching Placebo-Part A

Administered IV or SC in Part A

DRUG

Matching Placebo-Trevogrumab

Administered SC in Part B and Part C

DRUG

Matching Placebo-Garetosmab

Administered IV in Part B

Trial Locations (60)

16635

Altoona Center for Clinical Research, Duncansville

22911

Charlottesville Medical Research, Charlottesville

23606

Health Research of Hampton Roads, Inc., Newport News

27103

PMG Research of Winston-Salem, LLC, Winston-Salem

27157

Javara Incorporated at Wake Forest University Health Sciences, Winston-Salem

27609

Accellacare Clinical Research, Raleigh Medical Group, Raleigh

28144

Accellacare of Salisbury, Salisbury

28401

Pmg Research of Wilmington Llc, Wilmington

28625

Accellacare of Piedmont, Piedmont Healthcare, Statesville

29464

PMG Research of Charleston, Mt. Pleasant

29607

Tribe Clinical Research Llc, Greenville

30046

Balanced Life Health Care Solutions, Lawrenceville

30189

North Georgia Clinical Research, Woodstock

30501

Center for Advanced Research and Education, Gainesville

32205

Westside Center for Clinical Research, Jacksonville

32216

Jacksonville Center for Clinical Research, Jacksonville

33351

Precision Clinical Research, LLC, Sunrise

33606

Clinical Research of West Florida, Inc., Tampa

33709

IMA Clinical Research St. Petersburg, St. Petersburg

33880

Clinical Research of Central Florida - Bond Clinic, Winter Haven

33907

Southwest General Healthcare Center, Fort Myers

35055

Cullman Clinical Trials, Cullman

36207

Pinnacle Research Group, Anniston

37412

Chattanooga Medical Research, Chattanooga

37620

Pmg Research of Bristol, Bristol

37912

PMG Research of Knoxville - Merchant Drive, Knoxville

37938

PMG Research of Knoxville - Emory Road, Knoxville

38654

Olive Branch Family Medical Center, Olive Branch

39069

Prime Health and Wellness Clinic, Fayette

39157

Sky Integrative Medical Center Skycrng, Ridgeland

40213

L-MARC Research Center, Louisville

45219

Velocity Clinical Research Inc., Cincinnati

46617

The South Bend Clinic Center for Research, South Bend

55905

Mayo Clinic, Rochester

59701

Mercury Street Medical Group, PLLC, Butte

62701

Prairie Education and Research Cooperative (PERC), Springfield

65109

Jefferson City Medical Group, Jefferson City

65807

Clinvest Research, Springfield

66606

Cotton O'Neil Clinical Research Center, Topeka

70072

Tandem Clinical Research GI, LLC, Marrero

71201

IMA Clinical Research Monroe - Armand, Monroe

73069

AMR Norman, Norman

75230

Velocity Clinical Research Dallas, Dallas

76164

Valley Institute of Research, Fort Worth

78231

Consano Clinical Research, Shavano Park

79902

Medresearch Inc, El Paso

83221

Elite Clinical Trials LLLP, Blackfoot

85044

Foothills Research Center Cct Research, Phoenix

91356

Valiance Clinical Research- Huntington Park, Huntington Park

Metabolic Institute of America, Tarzana

Valiance Clinical Research, Tarzana

91911

ProSciento, Chula Vista

91941

Velocity, San Diego, La Mesa

92120

Acclaim Clinical Research, San Diego

92801

Anaheim Clinical Trials, Anaheim

95821

Northern California Research, Sacramento

96814

East-West Medical Research Institute, Honolulu

08009

Hassman Research Institute, Berlin

00927

Fundacion de Investigacion (FDI) Clinical Research, San Juan

PRCCI Clinical Research Center, San Juan

All Listed Sponsors
lead

Regeneron Pharmaceuticals

INDUSTRY