A Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007)

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

April 18, 2024

Primary Completion Date

March 5, 2026

Study Completion Date

March 5, 2026

Conditions
Carcinoma, Squamous CellSkin Neoplasms
Interventions
BIOLOGICAL

Pembrolizumab

IV Infusion

BIOLOGICAL

Intismeran autogene

IM injection

PROCEDURE

Surgery

Local resection of cancerous lesions of the skin

Trial Locations (106)

1023

Harbour Cancer & Wellness ( Site 3300), Auckland

1200

Cliniques universitaires Saint-Luc ( Site 1701), Brussels

2065

Melanoma Institute Australia-Clinical Trials Unit ( Site 3205), Wollstonecraft

3084

Austin Health ( Site 3209), Heidelberg

4029

Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Si, Brisbane

4032

Debreceni Egyetem Klinikai Kozpont-Bőrgyógyászati Klinika ( Site 2102), Debrecen

4120

Gallipoli Medical Research Ltd-GMRF CTU ( Site 3206), Greenslopes

4215

Gold Coast University Hospital-Cancer and Blood Disorders Clinical Trial Team ( Site 3207), Gold Coast

4575

Sunshine Coast University Hospital-Medical Oncology ( Site 3212), Birtinya

6009

One Clinical Research ( Site 3211), Nedlands

6720

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Közpo-Department of Dermatology and Allergol, Szeged

7600

Instituto de Investigaciones Clínicas Mar del Plata ( Site 1213), Mar del Plata

7632

Pécsi Tudományegyetem Klinikai Központ-Bőr-, Nemikórtani és Onkodermatológiai Klinika ( Site 2100), Pécs

9000

UZ Gent-Medical oncology ( Site 1702), Ghent

9024

Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz- Onkoradiologiai Osztaly ( Site 2110), Győr

10016

Laura and Isaac Perlmutter Cancer Center ( Site 1121), New York

11501

Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 1160), Mineola

12808

Vseobecna fakultni nemocnice v Praze-Department of Dermatology ( Site 1800), Prague

13005

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone ( Site 1903), Marseille

15009

Centro Oncologico de Galicia ( Site 2806), A Coruña

15232

UPMC Hillman Cancer Center ( Site 1107), Pittsburgh

16132

Ospedale San Martino-Oncologia Medica 2 ( Site 2303), Genoa

20089

Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 2304), Rozzano

21000

Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 1904), Dijon

22031

Inova Schar Cancer Institute ( Site 1108), Fairfax

22908

University of Virginia Health System ( Site 1115), Charlottesville

23538

Universitätsklinikum Schleswig-Holstein-Dermatology ( Site 2012), Lübeck

24127

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-UOC Oncologia ( Site 2305), Bergamo

28027

Clinica Universidad de Navarra-Medical Oncology ( Site 2807), Madrid

28034

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2801), Madrid

29010

H.R.U Malaga - Hospital General ( Site 2805), Málaga

30322

Winship Cancer Institute, Emory University ( Site 1151), Atlanta

31059

Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE ( Site 1908), Toulouse

33075

CHU de Bordeaux Hop St ANDRE ( Site 1902), Bordeaux

40536

University of Kentucky Chandler Medical Center ( Site 1101), Lexington

44093

Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu-Onco-Dermatology ( Site 1910), Nantes

44137

Klinikum Dortmund Klinikzentrum Mitte ( Site 2008), Dortmund

45147

Universitaetsklinikum Essen-Klinik für Dermatologie, Venerologie und Allergologie ( Site 2005), Essen

46014

Hospital General Universitario de Valencia-oncology service ( Site 2802), Valencia

52242

University of Iowa-Holden Comprehensive Cancer Center ( Site 1118), Iowa City

53100

Azienda Ospedaliero Universitaria Senese ( Site 2302), Siena

53792

University Hospital and UW Health Clinics ( Site 1119), Madison

55131

Universitätsmedizin Johannes Gutenberg Universität Mainz ( Site 2007), Mainz

57105

Avera Cancer Institute- Research ( Site 1161), Sioux Falls

59037

Hopital Claude Huriez - CHU de Lille ( Site 1907), Lille

63110

Washington University School of Medicine-Internal Medicine/Oncology ( Site 1100), St Louis

69120

NCT ( Site 2002), Heidelberg

69310

centre hospitalier lyon sud ( Site 1901), Pierre-Bénite

70121

Ochsner Clinic Foundation ( Site 1113), New Orleans

70124

Instituto Tumori Giovanni Paolo II ( Site 2301), Bari

72076

Universitaetsklinikum Tuebingen-Hautklinik ( Site 2003), Tübingen

75475

Hôpital Saint-Louis ( Site 1906), Paris

80131

Istituto Nazionale Tumori IRCCS Fondazione Pascale-s.c. melanoma, immunoterapia oncologica e terapi, Napoli

81675

klinikum rechts der isar der technischen universität münchen ( Site 2009), München

90033

USC/Norris Comprehensive Cancer Center ( Site 1112), Los Angeles

92663

Hoag Memorial Hospital Presbyterian ( Site 1122), Newport Beach

94304

Stanford Cancer Center ( Site 1109), Palo Alto

94800

Gustave Roussy ( Site 1909), Villejuif

95817

University of California Davis (UC Davis) Comprehensive Cancer Center ( Site 1103), Sacramento

97080

Universitaetsklinikum Wuerzburg-Department of Dermatology ( Site 2001), Würzburg

97213

Providence Portland Medical Center ( Site 1102), Portland

200542

Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2601), Craiova

407280

SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2602), Florești

660001

Oncologos del Occidente ( Site 1504), Pereira

720214

Sigmedical Services SRL ( Site 2603), Suceava

760032

Fundación Valle del Lili ( Site 1502), Santiago de Cali

1834111

Emek Medical Center ( Site 2203), Afula

4800827

James Lind Centro de Investigacion del Cancer ( Site 1411), Temuco

4810218

CIDO SpA-Oncology ( Site 1405), Temuco

4941492

Rabin Medical Center ( Site 2202), Petah Tikva

5265601

Sheba Medical Center ( Site 2200), Ramat Gan

7500921

FALP-UIDO ( Site 1401), Santiago

7650568

Clínica Alemana de Santiago-Gynecology and Obstetrics ( Site 1410), Santiago

9112001

Hadassah Medical Center ( Site 2201), Jerusalem

88501001

ANIMI - Unidade de Tratamento Oncologico ( Site 1312), Lages

02114

Massachusetts General Hospital ( Site 1162), Boston

02215

Dana-Farber Cancer Institute ( Site 1130), Boston

07601

John Theurer Cancer Center at Hackensack University Medical Center ( Site 1125), Hackensack

07960

Atlantic Health System Morristown Medical Center ( Site 1136), Morristown

S2000DEJ

Fundacion Estudios Clinicos-Oncology ( Site 1205), Rosario

C1187AAN

Sanatorio Finochietto ( Site 1202), Buenos Aires

C1425BGH

Investigaciones Clinicas Moleculares (ICM) ( Site 1212), CABA

X5004BAL

Hospital Italiano de Córdoba ( Site 1204), Córdoba

41950-640

Clinica Amo - Rio Vermelho-INSTITUTO ETICA ( Site 1315), Salvador

86015-520

Hospital de Cancer de Londrina-Clinical Research Unit ( Site 1316), Londrina

99010-080

Associação Hospitalar Beneficente São Vicente de Paulo-Instituto do Câncer ( Site 1309), Passo Fundo

91350-200

Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 1300), Porto Alegre

15090-000

Fundação Faculdade Regional de Medicina de São José do Rio Preto-Centro Integrado de Pesquisa ( Site, São José do Rio Preto

01223-001

IPITEC ( Site 1313), São Paulo

H3T 1E2

Jewish General Hospital ( Site 1009), Montreal

J1H 5H4

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer, Sherbrooke

050030

Fundacion Colombiana de Cancerología Clinica Vida ( Site 1501), Medellín

0379

Oslo universitetssykehus, Radiumhospitalet ( Site 2400), Oslo

61-485

Centrum Medyczne HCP ( Site 2505), Poznan

85-796

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2501), Bydgoszcz

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warsaw

80-952

Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 2506), Gdansk

25-734

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch, Kielce

011461

Spitalul Universitar de Urgență Elias ( Site 2600), Bucharest

08916

Hospital Germans Trias i Pujol-Instituto Catalán de Oncología de Badalona ( Site 2804), Badalona

08036

HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Sit, Barcelona

08035

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2803), Barcelona

CB2 2QQ

Addenbrooke's Hospital-Cambridge Cancer Trials Centre ( Site 3103), Cambridge

Pl6 8DH

Derriford Hospital-Oncology ( Site 3104), Plymouth

HU16 5JQ

Castle Hill Hospital ( Site 3102), Cottingham

SA2 8QA

Singleton Hospital-South West Wales Cancer Institute ( Site 3100), Swansea

All Listed Sponsors
collaborator

ModernaTX, Inc.

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT06295809 - A Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007) | Biotech Hunter | Biotech Hunter