Stopping Pneumonia Antibiotherapy Regimen Early

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

1,100

Participants

Timeline

Start Date

September 1, 2024

Primary Completion Date

May 1, 2027

Study Completion Date

September 1, 2027

Conditions
Community-acquired PneumoniaChild, Only
Interventions
DRUG

Quick response: Amoxicillin for 3 days

"Once the diagnosis of community-acquired alveolar pneumonia has been made, the investigator taking charge of the child writes a prescription for amoxicillin at a dosage of 80-100 mg/kg/day in 3 oral doses (morning, noon and evening), for a period of 4 days, before delivery of treatment to the family. The investigator will carry out a clinical re-evaluation on day 3 (D3), during which he will decide on the final duration of treatment.~In case of rapid response\*: Immediate stop of antibiotherapy (after 9 complete doses)~\*A rapid response is determined by a favorable clinical evolution (MASCOT 2002 study)"

DRUG

Delayed response: Amoxicillin for 5 days

"Once the diagnosis of community-acquired alveolar pneumonia has been made, the investigator taking charge of the child writes a prescription for amoxicillin at a dosage of 80-100 mg/kg/day in 3 oral doses (morning, noon and evening), for a period of 4 days, before delivery of treatment to the family. The investigator will carry out a clinical re-evaluation on day 3 (D3), during which he will decide on the final duration of treatment.~In case of delayed response: Continuation of antibiotic therapy for up to 5 days"

DRUG

Quick response: Amoxicillin for 5 days

"Once the diagnosis of community-acquired alveolar pneumonia has been made, the investigator taking charge of the child writes a prescription for amoxicillin at a dosage of 80-100 mg/kg/day in 3 oral doses (morning, noon and evening), for a period of 4 days, before delivery of treatment to the family. The investigator will carry out a clinical re-evaluation on day 3 (D3), during which he will decide on the final duration of treatment.~In case of rapid response\*: Continuation of antibiotherapy for up to 5 days~\*A rapid response is determined by a favorable clinical evolution (MASCOT 2002 study)"

DRUG

Delayed response: Amoxicillin for 7 days

"Once the diagnosis of community-acquired alveolar pneumonia has been made, the investigator taking charge of the child writes a prescription for amoxicillin at a dosage of 80-100 mg/kg/day in 3 oral doses (morning, noon and evening), for a period of 4 days, before delivery of treatment to the family. The investigator will carry out a clinical re-evaluation on day 3 (D3), during which he will decide on the final duration of treatment.~In case of delayed response: Continuation of antibiotic therapy for up to 7 days"

Trial Locations (1)

34295

CHU de Montpellier, Montpellier

All Listed Sponsors
collaborator

Direction Générale de l'Offre de Soins

OTHER_GOV

lead

University Hospital, Montpellier

OTHER

NCT06291012 - Stopping Pneumonia Antibiotherapy Regimen Early | Biotech Hunter | Biotech Hunter