Neoadjuvant Chemoimmunotherapy Versus Concurrent Chemoradiotherapy for LACC

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

440

Participants

Timeline

Start Date

April 22, 2024

Primary Completion Date

March 1, 2031

Study Completion Date

March 1, 2031

Conditions
Cervical CancerLocally Advanced Cervical CancerConcurrent ChemoradiotherapyNeoadjuvant Chemoimmunotherapy
Interventions
DRUG

Camrelizumab

Camrelizumab is administered at 200mg, q3w (second and third cycles) before radical surgery

DRUG

Cisplatin

Cisplatin:75-80mg/m2, D1-D2,q3w (3 cycles),intravenous infusion, administered at a rate of 1mg/min.

DRUG

Nab paclitaxel

Nab paclitaxel: 260 mg/m2,D1,q3w (3 cycles),intravenous infusion, administered over 30min.

PROCEDURE

Radical surgery

Radical surgery

RADIATION

external beam radiation therapy (EBRT) + brachytherapy

Radiation therapy per standard of care

DRUG

Cisplatin

Chemotherapy administered concurrent with radiation therapy,cisplatin 40 mg/m2 IV once per week (QW) for 5 weeks

Trial Locations (12)

230000

RECRUITING

Anhui Provincial Cancer Hospital, Hefei

310022

RECRUITING

Women's Hospital, Zhejiang University School of Medicine, Hangzhou

RECRUITING

Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou

400038

RECRUITING

The First Affiliated Hospital (Southwest Hospital), Army Medical University (Third Military Medical University), Chongqing

410008

RECRUITING

Xiangya Hospital, Central South University, Changsha

430030

RECRUITING

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

530021

RECRUITING

The Affiliated Tumor Hospital of Guangxi Medical University, Nanning

610041

RECRUITING

Second People's Hospital of Sichuan (Sichuan Cancer Hospital), Chengdu

730050

RECRUITING

Gansu Provincial Maternity and Child-care Hospital, Lanzhou

Unknown

RECRUITING

Beiing Friendship Hospital, Capital Medical University, Beijing

RECRUITING

Shengjing Hospital of China Medical University, Shenyang

RECRUITING

Tianjin Medical University General Hospital, Tianjin

All Listed Sponsors
collaborator

Southwest Hospital, China

OTHER

collaborator

Women's Hospital School Of Medicine Zhejiang University

OTHER

collaborator

Anhui Provincial Cancer Hospital

OTHER

collaborator

Sichuan Cancer Hospital and Research Institute

OTHER

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

Beijing Friendship Hospital

OTHER

collaborator

Tianjin Medical University General Hospital

OTHER

collaborator

West China Second University Hospital

OTHER

collaborator

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

OTHER

collaborator

Xiangya Hospital of Central South University

OTHER

collaborator

Gansu Provincial Maternal and Child Health Care Hospital

OTHER

collaborator

Zhejiang Cancer Hospital

OTHER

collaborator

Shengjing Hospital

OTHER

collaborator

Cancer Hospital of Guangxi Medical University

OTHER

lead

Tongji Hospital

OTHER