790
Participants
Start Date
June 7, 2024
Primary Completion Date
November 30, 2028
Study Completion Date
April 30, 2034
Mosunetuzumab
5 mg (step-up dosing) Day 1 of C1 45 mg Day 8 and Day 15 of C1, 45 mg Day 1 from C2 to C12, 45 mg Day 1 from C13 to C21
Lenalidomide
20 mg/day Day 1 to Day 21 from C2 to C12
Rituximab
when associated to CHOP IV 375mg/m² SC 1400 mg allowed from C2 Day 1 of C1 Day 1 from C2 to C6 Day 1 from C7 to C20
Obinutuzumab
when associated to CHOP 1000 mg Day 1, Day 8, Day 15 of C1 Day 1 from C2 to C8 Day 1 from C9 to C18
Cyclophosphamide
750 mg/m2 Day 1 from C1 to C6
Doxorubicin
50 mg/m2 Day 1 from C1 to C6
Vincristin
1.4 mg/m2 (cap cf. below)$ Day 1 from C1 to C6
Prednisone
100 mg/day Day 1 to Day 5 from C1 to C6
Rituximab
when associated to bendamustin IV 375mg/m² SC 1400 mg allowed from C2 Day 1 of C1 Day 1 from C2 to C6 Day 1 from C7 to C18
Obinutuzumab
when associated to bendamustin 1000 mg Day 1, Day 8, Day 15 of C1 Day 1 from C2 to C8 Day 1 from C9 to C20
Bendamustin
90 mg/m2 Day 1 and Day 2 from C1 to C6
RECRUITING
INSTITUT JULES BORDET - Service Hématologie, Brussels
RECRUITING
INSTITUTO PORTUGUES DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL - Departamento Hematologia, Lisbon
RECRUITING
UNIVERSITE CATHOLIQUE DE LOUVAIN SAINT-LUC - Service Hématologie, Brussels
RECRUITING
CHU DE LIEGE - Service Hématologie, Liège
RECRUITING
CHR VERVIERS - LA TOURELLE - Service Hématologie, Verviers
RECRUITING
CHU UCL NAMUR - SITE GODINNE - Service Hématologie, Yvoir
RECRUITING
GRAND HOPITAL DE CHARLEROI - Service Hématologie, Charleroi
RECRUITING
AZ SINT-JAN BRUGGE - OOSTENDE AV - Service Hématologie, Bruges
RECRUITING
UNIVERSITAIR ZIEKENHUIS GENT - Service Hématologie, Ghent
RECRUITING
INSTITUT PAOLI CALMETTES - Service Hématologie, Marseille
RECRUITING
CHU DIJON BOURGOGNE - Service Hématologie Clinique, Dijon
RECRUITING
CHU JEAN MINJOZ - Service Hématologie, Besançon
RECRUITING
IUCT ONCOPOLE - Service Hématologie, Toulouse
RECRUITING
INSTITUT BERGONIE - Service d'Oncologie Médicale, Bordeaux
RECRUITING
CHU DE BORDEAUX - HOPITAL HAUT-LEVEQUE - CENTRE FRANCOIS MAGENDIE - Service d'Hématologie et Thérapie Cellulaire, Pessac
RECRUITING
CHU DE MONTPELLIER - Département d'Hématologie Clinique, Montpellier
RECRUITING
CHU PONTCHAILLOU - Hématologie Clinique, Rennes
RECRUITING
HOSPITAL CLINICO SALAMANCA - Servicio de Hematologia, Salamanca
RECRUITING
CHU BRETONNEAU - Service Cancérologie - Hématologie et Thérapie Cellulaire, Tours
RECRUITING
CHU DE GRENOBLE - Service Hématologie, La Tronche
RECRUITING
Institut de Cancérologie et d'Hématologie Universitaire de Saint-Étienne - Service Hématologie, Saint-Priest-en-Jarez
RECRUITING
CHU DE NANTES - Service Hématologie, Nantes
RECRUITING
CENTRE HOSPITALIER JEAN ROUGIER - Service d'Oncologie - Hématologie, Cahors
RECRUITING
CHU BRABOIS - Service Hématologie, Vandœuvre-lès-Nancy
RECRUITING
CH DE BRETAGNE ATLANTIQUE - HOPITAL CHUBERT - Service Hématologie, Vannes
RECRUITING
CHU DE REIMS - HOPITAL ROBERT DEBRE - Service Hématologie, Reims
RECRUITING
HOPITAL SAINT VINCENT-DE-PAUL - Service Hématologie, Lille
RECRUITING
CHRU DE LILLE - HOPITAL CLAUDE HURIEZ - Service Hématologie, Lille
RECRUITING
CH DE VALENCIENNES - HOPITAL JEAN BERNARD - Service Hématologie, Valenciennes
RECRUITING
CHU ESTAING - Service Thérapie Cellulaire et Hématologie Clinique, Clermont-Ferrand
RECRUITING
CH DE LA COTE BASQUE - Service Hématologie, Bayonne
RECRUITING
INSTITUT DE CANCEROLOGIE STRASBOURG EUROPE - Unité de Recherche Clinique, Strasbourg
RECRUITING
GH REGION MULHOUSE ET SUD ALSACE - HOPITAL EMILE MULLER - Service Hématologie, Mulhouse
RECRUITING
CHU LYON-SUD - Hématologie, Pierre-Bénite
RECRUITING
CH METROPOLE SAVOIE - SITE CHAMBERY - Service Hématologie, Chambéry
RECRUITING
CH ANNECY GENEVOIS - SITE D'ANNECY - Service Hématologie, Pringy
RECRUITING
HOPITAL SAINT-LOUIS - Service Hématologie, Paris
RECRUITING
CENTRE HENRI BECQUEREL - Service Hématologie, Rouen
RECRUITING
CHI POISSY SAINT-GERMAIN-EN-LAYE - Service Hématologie, Poissy
RECRUITING
CENTRE HOSPITALIER DE NIORT - Médecine interne, Niort
RECRUITING
CH d'AVIGNON - HOPITAL HENRI DUFFAUT - Service d'Onco-Hématologie, Avignon
RECRUITING
CHD DE VENDEE - Service Hématologie, La Roche-sur-Yon
RECRUITING
CHU DE POITIERS - HOPITAL DE LA MILETRIE - Service d'Oncologie Hématologique et Thérapie Cellulaire, Poitiers
RECRUITING
CHU DE LIMOGES - HOPITAL DUPUYTREN - Service Hématologie Clinique et Thérapie Cellulaire, Limoges
RECRUITING
UNIV KLINIKUM ULM - INNERE MEDIZIN III - Service Hématologie, Ulm
RECRUITING
INSTITUT CURIE - SITE SAINT-CLOUD - Service Hématologie, Saint-Cloud
RECRUITING
UNIVERSITATSKLINIKUM REGENSBURG - Klinik für Innere Medizin III, Regensburg
RECRUITING
HOPITAL HENRI MONDOR - Unité Hémopathies Lymphoïdes, Créteil
RECRUITING
GUSTAVE ROUSSY CANCER CAMPUS GRAND PARIS - Département Médecine Oncologique, Villejuif
Lymphoma Study Association
OTHER
Swiss Cancer Institute
OTHER
Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea
OTHER
The Lymphoma Academic Research Organisation
OTHER