Intermittent Hypoxia in Persons With Multiple Sclerosis

NARecruitingINTERVENTIONAL
Enrollment

21

Participants

Timeline

Start Date

April 30, 2024

Primary Completion Date

January 31, 2026

Study Completion Date

January 31, 2027

Conditions
Multiple SclerosisMultiple Sclerosis-Relapsing-RemittingMultiple Sclerosis, Secondary Progressive
Interventions
OTHER

Acute Intermittent Hypoxia

During each AIH session, the participant will be equipped with a non-rebreathing face mask, and provided with the AIH intervention. The AIH intervention involves alternating breathing cycles: one with lower oxygen concentration (9-10% Oxygen) than that at sea level (\~21% Oxygen) lasting between 30 and 60 seconds, followed by a similar duration of normal room air (21% Oxygen). This cycle will be repeated 15 times in one session, continuous blood oxygen levels and heart rate will be monitored.

OTHER

Sham-Acute Intermittent Hypoxia

During each Sham-AIH session, the participant will be equipped with a non-rebreathing face mask, and provided with the Sham-AIH intervention. The Sham-AIH intervention involves alternating breathing cycles: both with oxygen concentrations of \~21% Oxygen lasting between 30 and 60 seconds, followed by another similar duration of normal room air (21% Oxygen). This cycle will be repeated 15 times in one session, continuous blood oxygen levels and heart rate will be monitored.

Trial Locations (1)

60611

RECRUITING

Shirley Ryan AbilityLab, Chicago

All Listed Sponsors
collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

collaborator

Northwestern University

OTHER

lead

Shirley Ryan AbilityLab

OTHER