DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients with Metastatic Colorectal Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

587

Participants

Timeline

Start Date

July 1, 2024

Primary Completion Date

June 30, 2028

Study Completion Date

December 31, 2028

Conditions
Older PatientsColorectal CancerMetastatic CancerCandidates for Palliative Chemotherapy
Interventions
DRUG

Doublet Chemotherapy, Standard Dose (100%)

Capecitabine 1000mg / m2 oral at day 1-14 (every 3 weeks) Oxaliplatin 130mg/m2 at day 1 (every 3 weeks) OR 5-FU 400mg/m2 IV bolus at day 1 followed by 2400mg/m2 in 46 hours (every 2 weeks) Leucovorin 400mg/m2 day 1 (every 2 weeks) Oxaliplatin 85mg/m2 day 1 (every 2 weeks)

DRUG

Doublet Chemotherapy, Dose-reduced (75%)

75% of: Capecitabine 1000mg / m2 oral at day 1-14 (every 3 weeks) Oxaliplatin 130mg/m2 at day 1 (every 3 weeks) OR 5-FU 400mg/m2 IV bolus at day 1 followed by 2400mg/m2 in 46 hours (every 2 weeks) Leucovorin 400mg/m2 day 1 (every 2 weeks) Oxaliplatin 85mg/m2 day 1 (every 2 weeks)

DRUG

Monotherapy, Standard Dose (100%)

\- Capecitabine 1000mg/m2 oral at day 1-14 (every 3 weeks)

DRUG

Monotherapy, Dose-reduced (75%)

"75% of:~\- Capecitabine 1000mg/m2 oral at day 1-14 (every 3 weeks)"

Trial Locations (36)

Unknown

NOT_YET_RECRUITING

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

NOT_YET_RECRUITING

Noordwest Ziekenhuisgroep, Alkmaar

NOT_YET_RECRUITING

Ziekenhuis Amstelland, Amstelveen

NOT_YET_RECRUITING

Amsterdam UMC, Amsterdam

NOT_YET_RECRUITING

Rijnstate, Arnhem

NOT_YET_RECRUITING

Wilhelmina Ziekenhuis, Assen

NOT_YET_RECRUITING

Rode Kruis Ziekenhuis, Beverwijk

NOT_YET_RECRUITING

Slingeland Ziekenhuis, Doetinchem

NOT_YET_RECRUITING

Ziekenhuis Gelderse Vallei, Ede

RECRUITING

Catharina Ziekenhuis, Eindhoven

NOT_YET_RECRUITING

Treant, Emmen

NOT_YET_RECRUITING

Admiraal de Ruyter Ziekenhuis, Goes

NOT_YET_RECRUITING

Beatrixziekenhuis, Gorinchem

RECRUITING

Groene Hart Ziekenhuis, Gouda

NOT_YET_RECRUITING

Saxenburgh, Hardenberg

NOT_YET_RECRUITING

St. Jansdal Ziekenhuis, Harderwijk

RECRUITING

Elkerliek Ziekenhuis, Helmond

RECRUITING

Tergooi MC, Hilversum

NOT_YET_RECRUITING

Medisch Centrum Leeuwarden, Leeuwarden

RECRUITING

Leiden University Medical Center, Leiden

NOT_YET_RECRUITING

Alrijne Ziekenhuis, Leiderdorp

NOT_YET_RECRUITING

Canisius Wilhelmina Ziekenhuis, Nijmegen

NOT_YET_RECRUITING

Laurentius Ziekenhuis, Roermond

RECRUITING

Bravis ziekenhuis, Roosendaal

RECRUITING

Ikazia Ziekenhuis, Rotterdam

NOT_YET_RECRUITING

Maasstad Ziekenhuis, Rotterdam

NOT_YET_RECRUITING

Ommelander Ziekenhuis, Scheemda

RECRUITING

ZorgSaam Zorggroep Zeeuws-Vlaanderen, Terneuzen

NOT_YET_RECRUITING

Haaglanden Medisch Centrum, The Hague

RECRUITING

Hagaziekenhuis, The Hague

NOT_YET_RECRUITING

Bernhoven, Uden

NOT_YET_RECRUITING

Diakonessenhuis, Utrecht

NOT_YET_RECRUITING

St Antonius, Utrecht

NOT_YET_RECRUITING

VieCuri Medisch Centrum, Venlo

RECRUITING

Streekziekenhuis Koninging Beatrix, Winterswijk

NOT_YET_RECRUITING

Zaans Medisch Centrum, Zaandam

All Listed Sponsors
collaborator

Dutch Colorectal Cancer Group

OTHER

lead

Leiden University Medical Center

OTHER