Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

310

Participants

Timeline

Start Date

March 20, 2024

Primary Completion Date

March 18, 2027

Study Completion Date

March 18, 2027

Conditions
Alzheimer Disease, Early Onset
Interventions
DRUG

BMS-986446

Specified dose on specified days

OTHER

Placebo

Specified dose on specified days

Trial Locations (176)

1070

Local Institution - 0122, Anderlecht

1200

Local Institution - 0097, Brussels

2018

Local Institution - 0175, Antwerpen

2113

Local Institution - 0170, Macquarie Park

2250

Local Institution - 0111, East Gosford

3000

Local Institution - 0076, Leuven

3050

Local Institution - 0147, Parkville

3053

Local Institution - 0115, Carlton North

3081

Local Institution - 0093, Ivanhoe

3144

Local Institution - 0001, Malvern

4222

Local Institution - 0116, Griffith University

6009

Local Institution - 0094, Nedlands

8500

Local Institution - 0082, Kortrijk

21565

Local Institution - 0050, Incheon

22332

Local Institution - 0114, Junggu

23294

Local Institution - 0168, Richmond

25006

Local Institution - 0231, Lleida

32159

Local Institution - 0151, Lady Lake

32751

Local Institution - 0143, Maitland

32792

Local Institution - 0154, Winter Park

32807

Local Institution - 0219, Orlando

32832

Local Institution - 0238, Orlando

33032

Local Institution - 0203, Miami

33126

Local Institution - 0211, Miami

33135

Local Institution - 0013, Miami

33144

Local Institution - 0199, Miami

33176

Local Institution - 0225, Miami

33467

Local Institution - 0059, Greenacres City

34105

Local Institution - 0217, Naples

34205

Local Institution - 0224, Bradenton

34471

Local Institution - 0144, Ocala

37212

Local Institution - 0222, Nashville

44131

Local Institution - 0155, Independence

60031

Local Institution - 0003, Gurnee

60068

Local Institution - 0145, Park Ridge

77702

Local Institution - 0033, Beaumont

85004

Local Institution - 0019, Phoenix

85253

Local Institution - 0018, Scottsdale

95816

Local Institution - 0209, Sacramento

119228

Local Institution - 0091, Singapore

1130034

Local Institution - 0185, Bunkyo-Ku

1588531

Local Institution - 0184, Setagaya-Ku

4570818

Local Institution - 0181, Nagoya

85226-3732

Local Institution - 0068, Chandler

85297-0441

Local Institution - 0102, Gilbert

85258-4595

Local Institution - 0026, Scottsdale

85718-6522

Local Institution - 0077, Tucson

85718-6632

Local Institution - 0038, Tucson

91316-1511

Local Institution - 0164, Encino

92835-1040

Local Institution - 0139, Fullerton

92614-9403

Local Institution - 0191, Irvine

90804-2128

Local Institution - 0234, Long Beach

90720-3589

Local Institution - 0142, Los Alamitos

94558-2415

Local Institution - 0037, Napa

94143-2350

Local Institution - 0052, San Francisco

92705-8675

Local Institution - 0137, Santa Ana

91403-2131

Local Institution - 0046, Sherman Oaks

06810-4088

Local Institution - 0106, Danbury

06510

Local Institution - 0148, New Haven

06511-5249

Local Institution - 0056, New Haven

06905-1206

Local Institution - 0153, Stamford

32714-2436

Local Institution - 0022, Altamonte Springs

33462-6631

Local Institution - 0048, Atlantis

33428-2236

Local Institution - 0228, Boca Raton

33487-3626

Local Institution - 0250, Boca Raton

34711-5933

Local Institution - 0020, Clermont

32117-5532

Local Institution - 0009, Daytona Beach

33912-4302

Local Institution - 0213, Fort Myers

33012-4170

Local Institution - 0207, Hialeah

33015-5110

Local Institution - 0212, Hialeah

33016-1814

Local Institution - 0198, Hialeah

33805-2208

Local Institution - 0146, Lakeland

32751-3320

Local Institution - 0192, Maitland

32952-3616

Local Institution - 0027, Merritt Island

33122-1335

Local Institution - 0058, Miami

33125-4719

Local Institution - 0034, Miami

33133-4231

Local Institution - 0195, Miami

33135-2957

Local Institution - 0014, Miami

33135-2968

Local Institution - 0005, Miami

33135-4759

Local Institution - 0208, Miami

33137-2706

Local Institution - 0008, Miami

33155-4630

Local Institution - 0206, Miami

33155-6540

Local Institution - 0176, Miami

33166-2710

Local Institution - 0071, Miami

33175-3598

Local Institution - 0156, Miami

33176-2151

Local Institution - 0249, Miami

33176-7947

Local Institution - 0039, Miami

33166-7225

Local Institution - 0197, Miami Springs

34652-4020

Local Institution - 0017, New Port Richey

32806-8521

Local Institution - 0202, Orlando

32819-8031

Local Institution - 0035, Orlando

32127-5170

Local Institution - 0210, Port Orange

34239-3228

Local Institution - 0204, Sarasota

34997-5765

Local Institution - 0012, Stuart

34997-6405

Local Institution - 0136, Stuart

33607-6210

Local Institution - 0200, Tampa

33607-6616

Local Institution - 0080, Tampa

33609-4049

Local Institution - 0087, Tampa

33613-4808

Local Institution - 0042, Tampa

32940-7948

Local Institution - 0194, Viera

33414-9320

Local Institution - 0011, Wellington

33407-3234

Local Institution - 0223, West Palm Beach

33409-6611

Local Institution - 0149, West Palm Beach

34786-8919

Local Institution - 0029, Windermere

32789-1848

Local Institution - 0101, Winter Park

31909-1692

Local Institution - 0105, Columbus

60611-2818

Local Institution - 0236, Chicago

60640-2831

Local Institution - 0021, Chicago

60007-3362

Local Institution - 0161, Elk Grove Village

62702-4968

Local Institution - 0081, Springfield

02116

Local Institution - 0235, Boston

02131-2515

Local Institution - 0025, Boston

02184

Local Institution - 0015, Braintree

02035-1309

Local Institution - 0174, Foxborough

01844-5864

Local Institution - 0118, Methuen

02459-3328

Local Institution - 0040, Newton

02360-7223

Local Institution - 0120, Plymouth

02472-4153

Local Institution - 0045, Watertown

03801-6822

Local Institution - 0119, Portsmouth

08540-2859

Local Institution - 0031, Princeton

08755-5043

Local Institution - 0062, Toms River

12208-3464

Local Institution - 0060, Albany

14226-1727

Local Institution - 0157, Amherst

11030-3816

Local Institution - 0061, Manhasset

10029-5611

Local Institution - 0205, New York

Local Institution - 0214, New York

10029-6504

Local Institution - 0104, New York

10032-3726

Local Institution - 0133, New York

28105-8336

Local Institution - 0043, Matthews

45459-4296

Local Institution - 0215, Dayton

19462-7401

Local Institution - 0023, Plymouth Meeting

02914

Local Institution - 0024, East Providence

02906-4800

Local Institution - 0163, Providence

38018-4254

Local Institution - 0132, Cordova

37067-5922

Local Institution - 0140, Franklin

78757-8046

Local Institution - 0069, Austin

75231-4316

Local Institution - 0051, Dallas

77074-1812

Local Institution - 0016, Houston

22031-5216

Local Institution - 0196, Fairfax

03181

Local Institution - 0125, Melbourne

K1Z 8R7

Local Institution - 0112, Ottawa

M3B 2S7

Local Institution - 0047, Toronto

M5T 2S8

Local Institution - 0044, Toronto

M6A 2E1

Local Institution - 0109, Toronto

J4V 2J2

Local Institution - 0113, Greenfield Park

H4A 3T2

Local Institution - 0248, Montreal

G3K 2P8

Local Institution - 0053, Québec

302-0004

Local Institution - 0227, Toride-Shi

710-0813

Local Institution - 0186, Kurashiki-Shi

573-1121

Local Institution - 0242, Hirakata-Shi

556-0015

Local Institution - 0253, Osaka

192-0071

Local Institution - 0218, Hachioji-Shi

104-0031

Local Institution - 0226, Chūōku

670-8560

Local Institution - 0190, Himeji-shi

344-0036

Local Institution - 0188, Kasukabe-Shi

187-8551

Local Institution - 0179, Kodaira-Shi

208-0022

Local Institution - 0221, Musashimurayama-Shi

180-8610

Local Institution - 0220, Musashino-shi

451-0052

Local Institution - 0180, Nagoya

545-8586

Local Institution - 0178, Osaka

474-8511

Local Institution - 0232, Ōbu

190-0022

Local Institution - 0240, Tachikawa-Shi

569-1192

Local Institution - 0239, Takatsuki-Shi

560-0004

Local Institution - 0189, Toyonaka-Shi

138-736

Local Institution - 0117, Songpa-gu

143-729

Local Institution - 0110, Gwangjingu

08036

Local Institution - 0158, Barcelona

08195

Local Institution - 0054, Sant Cugat del Vallès

08003

Local Institution - 0096, Barcelona

08035

Local Institution - 0171, Barcelona

08041

Local Institution - 0172, Barcelona

212 24

Local Institution - 0167, Malmo

EN3 4GS

Local Institution - 0121, Enfield

EC2Y 8EA

Local Institution - 0252, London

BA1 3NG

Local Institution - 0247, Bath

KT16 9AU

Local Institution - 0089, Chertsey

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY

NCT06268886 - Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease | Biotech Hunter | Biotech Hunter