Microbiological Structure of Pathogens of Periprosthetic Infection of Large Joints in the Post-Covid Period

CompletedOBSERVATIONAL
Enrollment

342

Participants

Timeline

Start Date

January 1, 2018

Primary Completion Date

December 31, 2022

Study Completion Date

December 31, 2022

Conditions
Joint InfectionPeriprosthetic Left Knee Joint Infection
Interventions
DIAGNOSTIC_TEST

Microbiological examination of the patient's biological material and determination of antibiotic resistance

Isolated microorganisms were identified based on growth in one or more cultures obtained from punctate synovial fluid, intraoperative tissues, and from removed implants (after their ultrasonic treatment). At least 4 samples of intraoperative material (tissue biopsies, joint aspirate, removed endoprosthesis components) were taken from patients for examination. The endoprosthesis components removed during surgery were placed in a sterile plastic container and delivered to the laboratory. In the laboratory, saline solution was added to the container and processed in an ultrasonic machine according to the author's method. Identification of isolated microorganisms and sensitivity to antibiotics was carried out using an automatic analyzer and a semi-automatic analyzer using kits, test systems. Sensitivity to antibacterial drugs was tested using the disk diffusion method and analyzer kits. Antibiotic sensitivity assessment was carried out in accordance with the criteria of EUCAST.

Trial Locations (1)

429500

Federal Center for Traumatology, Orthopedics and Endoprosthetics, Cheboksary

All Listed Sponsors
lead

Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty

OTHER

NCT06267287 - Microbiological Structure of Pathogens of Periprosthetic Infection of Large Joints in the Post-Covid Period | Biotech Hunter | Biotech Hunter