Lenvatinib Plus DEB-TACE With/Without FOLFOX-HAIC for Large HCC With PVTT

CompletedOBSERVATIONAL
Enrollment

205

Participants

Timeline

Start Date

July 1, 2019

Primary Completion Date

December 31, 2022

Study Completion Date

December 31, 2022

Conditions
Hepatocellular Carcinoma Non-resectable
Interventions
PROCEDURE

Len+DEB-TACE+HAIC

Patients received TACE with drug-eluting beads and FOLFOX-HAIC. DEB-TACE and/or HAIC was repeated for viable tumors demonstrated by follow-up imaging in patients without worsening liver function or contraindications. Lenvatinib was orally administered at a dose of 12 mg/day (bodyweight 60 kg) or 8mg/day (bodyweight \<60 kg). It was initiated within 7 days after the first DEB-TACE or DEB-TACE+HAIC and continued until unacceptable toxicity or disease progression occurred.

PROCEDURE

Len+DEB-TACE

Patients received TACE with drug-eluting beads. DEB-TACE was repeated for viable tumors demonstrated by follow-up imaging in patients without worsening liver function or contraindications. Lenvatinib was orally administered at a dose of 12 mg/day (bodyweight 60 kg) or 8mg/day (bodyweight \<60 kg). It was initiated within 7 days after the first DEB-TACE or DEB-TACE+HAIC and continued until unacceptable toxicity or disease progression occurred.

Trial Locations (1)

510260

The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou

All Listed Sponsors
collaborator

Zhongshan People's Hospital, Guangdong, China

OTHER

collaborator

Affiliate Hospital of Guangdong Medical University

UNKNOWN

collaborator

Jieyang People's Hospital

OTHER

collaborator

Huizhou Municipal Central Hospital

OTHER

collaborator

Guangzhou Development District Hospital

UNKNOWN

collaborator

Affiliated Hospital of Nanjing University of Chinese Medicine

OTHER

collaborator

First People's Hospital of Foshan

OTHER

lead

Second Affiliated Hospital of Guangzhou Medical University

OTHER

NCT06265883 - Lenvatinib Plus DEB-TACE With/Without FOLFOX-HAIC for Large HCC With PVTT | Biotech Hunter | Biotech Hunter