Exploration of Fenestration Decompression Combined With Dalafenib in the Treatment of BRAF Mutant Ameloblastoma

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

March 1, 2024

Primary Completion Date

November 1, 2025

Study Completion Date

December 31, 2025

Conditions
Ameloblastoma
Interventions
DRUG

Dabrafenib

"Generic name: Dabrafenib mesylate capsules Dosage form: capsule Specifications: 50mg, calculated as C23H20F3N5O2S2 Usage: Orally The dose of dabrafenib is 150 mg twice daily (equivalent to a total daily dose of 300 mg), taken at least 1 hour before or 2 hours after a meal. If you miss a dose and it is less than 6 hours before the next dose, you should not take it.~Patients who undergo fenestrated decompression will be administered the drug for 8 weeks, with curettage performed between weeks 8 and 9. Patients undergoing curettage will continue to take dabrafenib preoperatively until a few hours before surgery, but ideally, patients will take dabrafenib within 12 hours before surgery."

All Listed Sponsors
lead

Shandong University

OTHER