VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

PHASE3RecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

July 11, 2024

Primary Completion Date

January 1, 2029

Study Completion Date

August 31, 2034

Conditions
Advanced Melanoma
Interventions
BIOLOGICAL

Vusolimogene Oderparepvec

Genetically modified Herpes Simplex Type 1 Virus.

BIOLOGICAL

Nivolumab

Anti-PD-1 Monoclonal Antibody

BIOLOGICAL

Nivolumab + Relatlimab

Nivolumab: Anti-PD-1 Monoclonal antibody. Relatlimab: A lymphocyte activation gene-3 (LAG-3) blocking antibody.

BIOLOGICAL

Pembrolizumab

A programmed death receptor-1 (PD-1)-blocking antibody indicated.

DRUG

Single-agent chemotherapy

Dacarbazine, temozolomide, or paclitaxel/albumin-bound paclitaxel.

Trial Locations (49)

10461

RECRUITING

Montefiore Medical Center, The Bronx

11042

RECRUITING

Northwell Health, R.J. Zuckerberg Cancer Center, Lake Success

11794

RECRUITING

Stony Brook University Cancer Center, Stony Brook

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15232

RECRUITING

UPMC, Pittsburgh

19107

RECRUITING

Thomas Jefferson University, Philadelphia

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

20010

RECRUITING

MedStar Washington Hospital Center, Washington D.C.

26506

RECRUITING

West Virginia University, Morgantown

27514

RECRUITING

University of North Carolina at Chapel Hill, Chapel Hill

27710

RECRUITING

Duke Cancer Center, Durham

30322

RECRUITING

Winship Cancer Institute, Emory University, Atlanta

33021

RECRUITING

Memorial Cancer Institute at Memorial Regional Hospital, Hollywood

33612

RECRUITING

Moffitt Cancer Center, Tampa

37920

RECRUITING

University of Tennessee, Knoxville

38138

RECRUITING

West Cancer Center and Research Institute, Germantown

40202

RECRUITING

University of Louisville Brown Cancer Center, Louisville

43210

RECRUITING

The Ohio State University- Martha Morehouse Tower, Columbus

48202

RECRUITING

Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion), Detroit

49503

RECRUITING

Corewell Health, Grand Rapids

52242

RECRUITING

University of Iowa, Iowa City

55455

RECRUITING

University of Minnesota, Minneapolis

60068

RECRUITING

Advocate Lutheran General Hospital, Park Ridge

60611

RECRUITING

Northwestern Memorial Hospital, Chicago

66205

RECRUITING

University of Kansas Cancer Center, Westwood

75246

RECRUITING

Texas Oncology, Dallas

75390

RECRUITING

University of Texas Southwestern Medical Center, Dallas

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

80045

RECRUITING

University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora

80113

RECRUITING

The Melanoma and Skin Cancer Institute, Englewood

84107

RECRUITING

Intermountain Health, Murray

84112

RECRUITING

Huntsman Cancer Institute, Salt Lake City

84790

RECRUITING

St. George Regional Hospital, St. George

85234

RECRUITING

Banner MD Anderson Cancer Center, Gilbert

90025

RECRUITING

The Angeles Clinic and Research Institute, Los Angeles

90033

RECRUITING

USC Norris Comprehensive Cancer Center, Los Angeles

90095

RECRUITING

UCLA Department of Medicine - Hematology/Oncology, Los Angeles

92037

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92868

RECRUITING

UC Irvine Health, Chao Family Comprehensive Cancer Center, Orange

94115

RECRUITING

San Francisco Oncology Associates, San Francisco

94143

RECRUITING

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

94304

RECRUITING

Stanford Cancer Institute, Palo Alto

95816

RECRUITING

Sutter Medical Group, Sacramento

03756

RECRUITING

Dartmouth Hitchcock Cancer Center, Lebanon

08103

RECRUITING

MD Anderson Cancer Center at Cooper, Camden

07601

RECRUITING

Hackensack University Medical Center, Hackensack

07960

RECRUITING

Morristown Medical Center - Atlantic Health System, Morristown

02903

RECRUITING

Rhode Island Hospital, Providence

05401

RECRUITING

University of Vermont Medical Center, Burlington

All Listed Sponsors
lead

Replimune Inc.

INDUSTRY