Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival

NARecruitingINTERVENTIONAL
Enrollment

3,992

Participants

Timeline

Start Date

May 29, 2024

Primary Completion Date

June 30, 2029

Study Completion Date

June 30, 2032

Conditions
Cancer SurgeryHypothermiaDeliriumLong-term Survivors
Interventions
OTHER

Routine thermal management

Patients assigned to routine thermal management will not be pre-warmed and ambient intraoperative temperature will be maintained near 20°C per routine. Only transfused blood will be warmed. An upper- or lower-body forced-air cover will be positioned over an appropriate non-operative site but will not initially be activated. Should core temperature decrease to 35.5°C, the warmer will be activated as necessary to prevent core temperature from decreasing further. The target nasopharyngeal temperature is 35.5°C.

OTHER

Target temperature management

"Pre-warming is performed with a full-body forced-air cover and electrically heated blanket for about 30 minutes before induction of anesthesia. The warmer will initially be set to high which corresponds to about 43°C. It will be subsequently adjusted to make patients feel warm, but not uncomfortably so. Patients will be warmed during surgery using two forced-air covers or combining forced-air covers with electric heating blanket when clinically practical. All intravenous fluids will be warmed to body temperature. There is no need to control ambient temperature since ambient temperature has little effect on core temperature in patients warmed with forced air. The target nasopharyngeal temperature is 36.8℃."

Trial Locations (34)

100007

NOT_YET_RECRUITING

Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing

100034

RECRUITING

Peking University First Hospital, Beijing

100055

RECRUITING

Guang'anmen Hospital China Academy of Chinese Medical Sciences, Beijing

100091

RECRUITING

Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing

100730

RECRUITING

Peking Union Medical College Hospital, Beijing

163711

RECRUITING

First Affiliated Hospital of Harbin Medical University, Harbin

210029

RECRUITING

Jiangsu Province Hospital, Nanjing

214023

NOT_YET_RECRUITING

The People's Hospital of Wuxi, Wuxi

214400

RECRUITING

Jiangyin People's Hospital, Jiangyin

230601

RECRUITING

The Second Affiliated Hospital of Anhui Medical University, Hefei

247099

NOT_YET_RECRUITING

The People's Hospital of Chizhou, Chizhou

250013

NOT_YET_RECRUITING

The First Affiliated Hospital Of Shandong First Medical University, Jinan

252000

RECRUITING

The People's Hospital of Liaocheng, Liaocheng

450052

RECRUITING

The First Affiliated Hospital Of Zhengzhou University, Zhengzhou

463599

NOT_YET_RECRUITING

Henan Provincial People's Hospital, Zhengzhou

518034

RECRUITING

Peking University Shenzhen Hospital, Shenzhen

610041

RECRUITING

Chengdu Seventh People's Hospital, Chengdu

610042

NOT_YET_RECRUITING

The First Affiliated Hospital of Anhui Medical University, Hefei

610072

NOT_YET_RECRUITING

Sichuan Provincial People's Hospital, Chengdu

610500

RECRUITING

The First Affiliated Hospital of Chengdu Medical College, Chengdu

710032

RECRUITING

Xijing Hospital, Fourth Military Medical University, Xi'an

Unknown

NOT_YET_RECRUITING

Maanshan People's Hospital, Ma’anshan

NOT_YET_RECRUITING

Aerospace Medical Center, Beijing

NOT_YET_RECRUITING

Beijing Chuanyangliu Hospital, Beijing

NOT_YET_RECRUITING

Beijing Coal Group General Hospital, Beijing

NOT_YET_RECRUITING

Beijing Electric Power Hospital, Beijing

NOT_YET_RECRUITING

The First Hospital of Tsinghua University, Beijing

RECRUITING

The First Affiliated Hospital of Chongqing Medical University, Chongqing

NOT_YET_RECRUITING

Jingzhou Central Hospital, Jingzhou

NOT_YET_RECRUITING

The First Affiliated Hospital of Kangda College of Nanjing Medical University ( Lianyungang First People's Hospital), Lianyungang

NOT_YET_RECRUITING

The Second Affiliated Hospital of Soochow University, Suzhou

NOT_YET_RECRUITING

The Second People's Hospital of Yibin (affiliated with West China Hospital of Sichuan University), Chengdu

NOT_YET_RECRUITING

Deyang People's Hospital, Deyang

050011

NOT_YET_RECRUITING

The Fourth Hospital of Hebei Medical University (Hebei Tumor Hospital), Shijiazhuang

All Listed Sponsors
collaborator

Peking University

OTHER

lead

Peking University First Hospital

OTHER