NCT06246942 - Physiology of Human Brain Connectivity | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

February 6, 2024

Primary Completion Date

April 15, 2027

Study Completion Date

April 15, 2027

Conditions

Healthy

Interventions

DEVICE

Single-pulse transcranial magnetic stimulation (spTMS)

Single-pulse TMS (spTMS) will be delivered with a TMS stimulator (MagPro X100 w/ MagOption, MagVenture, Farum, Denmark) and a figure-of-eight TMS coil. 80 spTMS will be repeated at 0.2 Hz. An MRI-based TMS navigation system will be used to navigate the TMS coil (Localite, Bonn, Germany).

DEVICE

Paired associative stimulation (PAS)

Paired associative stimulation (PAS) will be applied with two TMS stimulators (MagPro X100 w/ MagOption, MagVenture, Farum, Denmark) and two TMS coils. The pulses from each stimulator/coil will be repeated at 0.2 Hz, duration of run 15 minutes (180 pulses for each stimulator/coil). In different sessions, we will deliver PAS with different asynchrony values to examine their effects on effective connectivity. Coils will be navigated using an MRI-based TMS navigation system (Localite, Bonn, Germany).

DIAGNOSTIC_TEST

Magnetic resonance imaging (MRI)

Structural, diffusion, and functional MRI with a 3-Tesla Siemens scanner

All Listed Sponsors

collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

lead

Massachusetts General Hospital

OTHER