Effect of Ketamine, Amitriptyline and Their Combination on Itch

NACompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

August 20, 2024

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2024

Conditions
Itch
Interventions
DRUG

Ketamine 0.5%

Ketamine cream 0.5% will be applied in a 4x4 area in the forearm of each participant.

DRUG

Amitriptyline

Amitriptyline cream 1% will be applied in a 4x4 area in the forearm of each participant.

DRUG

ketamine + amitriptyline

A cream containing ketamine 0.5%, amitriptyline 1%, will be applied in a 4x4 area in the forearm of each participant.

OTHER

Vehicle

A vehicle cream will be applied in a 4x4 area in the forearm of each participant.

OTHER

Histamine

After the cream removal, itch will be induced using histamine in the first session

OTHER

Cowhage

After the cream removal, itch will be induced using cowhage in the second session

Trial Locations (1)

9260

Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University, Gistrup

All Listed Sponsors
lead

Aalborg University

OTHER

NCT06245564 - Effect of Ketamine, Amitriptyline and Their Combination on Itch | Biotech Hunter | Biotech Hunter