90
Participants
Start Date
December 2, 2024
Primary Completion Date
February 15, 2028
Study Completion Date
February 15, 2028
Repeated behavioural assessment
"One CRS-R per visit~* 4 SECONDs~* Eye tracking during every clinical assessment~* Recording every 2-4h of the Glasgow Coma Score~* Recording every 2h of the temperature and pupillometer reactivity to light"
Act-Pass paradigm
Before and after sedation withdrawal Assessment of infra-clinical response to an active paradigm (attention focalisation or diversion).
Biological measures of circadian and monoamines biomarkers
Systematic urinary sampling every 2 hours for melatonin, cortisol and monoamines metabolites
Transcriptomic and genomic analysis
Definition of the peripheral cellular clock by 2 transcriptomic measures Constitution of a genomic biobank to analyse the cofounding factors for circadian disruption and differential clinical recovery
Polysomnography with concomitant environment recording
"One 48h polysomnography for the first visit~\+ 3\* 24h polysomnography for each visit Synchronised recordings of light, sound, activity in patients' rooms"
Actimetry
Continuous recording of movements at the wrist during 7 days after sedation withdrawal
Morphological MRI
Precise description of brain lesion by a 3T MRI within the 1st week after sedation withdrawal
Assessment of correlation between patients' behaviour and neurophysiological markers of consciousness.
Video recording of spontaneous patients' movements in the bed and synchronized during 2h with high-density EEG.
RECRUITING
Service de Réanimation Polyvalente Neurologique Hôpital Neurologique Pierre Wertheimer, Bron
Hospices Civils de Lyon
OTHER