Del Nido Versus HTK Cardioplegia in Adult Aortic Valve Replacement

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

October 1, 2018

Primary Completion Date

April 24, 2023

Study Completion Date

September 24, 2024

Conditions
Aortic Valve DiseaseValve Disease, HeartCardiac Ischemia
Interventions
DRUG

Del Nido Cardioplegia Solution

The route of cardioplegia delivery differed according to surgeons' preferences. The total dosage of cardioplegia depends on the type of cardioplegia. The standard dose of del Nido cardioplegia in our institution is 1000 ml as an initial dose and is delivered with a system pressure of 90-150 mmHg. The solution is prepared by our hospital's pharmacy. At 60. minute of cross-clamp (XC) if XC time was expected to exceed 90 minutes another dose of solution would be delivered. The volume of an additional dose was 500 ml. The temperature of the delivered del Nido cardioplegia was 4\*C.

DRUG

HTK solution

The route of cardioplegia delivery differed according to surgeons' preferences. The dose of the HTK cardioplegia is calculated with an application of 20 mL/kg rule. It is delivered with a system pressure of 90-150 mmHg. If the XC time exceeds 120 minutes additional dose is given (10 mL/kg rule). The temperature of the delivered crystalloid cardioplegia is 4\*C

Trial Locations (1)

80-282

Medical University of Gdańsk, Gdansk

All Listed Sponsors
lead

Medical University of Gdansk

OTHER