Cladribine Venetoclax in Monocytic AML

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

February 8, 2024

Primary Completion Date

October 31, 2026

Study Completion Date

October 31, 2027

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Cladribine

A medication used to treat hairy cell leukemia (leukemic reticuloendotheliosis) and B-cell chronic lymphocytic leukemia. Cladribine, sold under the brand name Mavenclad, is used for the treatment of adults with highly active forms of relapsing-remitting multiple sclerosis.

DRUG

Venetoclax

A medication used to treat adults with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or acute myeloid leukemia (AML).

DRUG

Azacitidine

Medication used for the treatment of myelodysplastic syndrome, myeloid leukemia, and juvenile myelomonocytic leukemia. It is a chemical analog of cytidine, a nucleoside in DNA and RNA.. Azacitidine and its deoxy derivative, decitabine were first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer.

Trial Locations (1)

80045

RECRUITING

Universtiy of Colorado Hospital, Aurora

All Listed Sponsors
collaborator

The Leukemia and Lymphoma Society

OTHER

lead

University of Colorado, Denver

OTHER