Clinical Study of Lung Protective Ventilation Strategies and Tumor Microenvironment

NAEnrolling by invitationINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

January 25, 2024

Primary Completion Date

February 1, 2025

Study Completion Date

December 31, 2025

Conditions
Tumor Microenvironment
Interventions
PROCEDURE

Lung protective ventilation strategy

They were divided into 2 groups: traditional ventilation strategy group (control group) and lung protective ventilation strategy group (experimental group), with 30 cases in each group. In the conventional ventilation strategy group, the conventional ventilation strategies were followed: tidal volume (VT)=10-12ml/kg, respiratory rate(f) =12 times/minute, PEEP=0 cmH₂O, fraction of inspired oxygen=0.5; Lung protective ventilation strategies were implemented in the Lung protective ventilation strategy group: VT=6-8ml/kg, f=12 times/min, PEEP=6-8 cm H₂O,fraction of inspired oxygen=0.5 Manual lung reexpansion was performed every 30 minutes after mechanical ventilation (continuous positive airway pressure of 30 cm H₂O for 30 seconds).

Trial Locations (1)

226001

The Affiliated hospital of Nantong University, Nantong

All Listed Sponsors
lead

Affiliated Hospital of Nantong University

OTHER