A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

216

Participants

Timeline

Start Date

February 15, 2024

Primary Completion Date

May 14, 2027

Study Completion Date

May 14, 2027

Conditions
B-Cell Non-Hodgkin Lymphoma (B-NHL)
Interventions
DRUG

Odronextamab

Administered by intravenous (IV) infusion

DRUG

Ifosfamide

Administered by IV infusion, as part of the ICE ± R salvage therapy

DRUG

Carboplatin

Administered by IV infusion, as part of the ICE ± R salvage therapy

DRUG

Etoposide

Administered by IV infusion, as part of the ICE ± R salvage therapy

DRUG

Rituximab

Administered by IV infusion, as part of the ICE ± R, or DHAP ± R, or GDP ± R salvage therapy.

DRUG

Dexamethasone

Administered by IV, or orally (PO) as part of the DHAP ± R, or GDP ± R salvage therapy.

DRUG

Cisplatin

Administered by IV infusion, as part of the DHAP ± R or GDP +/-R salvage therapy.

DRUG

Cytarabine

Administered by IV infusion, as part of the DHAP ± R salvage therapy.

DRUG

Gemcitabine

Administered by IV infusion, as part of the GDP ± R salvage therapy.

Trial Locations (85)

613

RECRUITING

Chang Gung Medical Foundation, Chiayi City

704

RECRUITING

National Cheng Kung University Hospital, Tainan City

1426

RECRUITING

Instituto Alexander Fleming, Ciudad Autonoma de Buenos Aires

2170

WITHDRAWN

Liverpool Hospital, Liverpool

3084

RECRUITING

Olivia Newton John Cancer Wellness & Research Centre, Heidelberg

4102

RECRUITING

Princess Alexandra Hospital, Woolloongabba

7000

RECRUITING

Royal Hobart Hospital, Hobart

7624

RECRUITING

University of Pecs, Pécs

10002

RECRUITING

National Taiwan University Hospital, Taipei

10330

RECRUITING

Chulalongkorn University, Bangkok

10408

RECRUITING

National Cancer Center, Gyeonggi-do

10700

RECRUITING

Sriraj Hospital, Bangkok

11490

RECRUITING

Tri-Service General Hospital, Taipei

16247

RECRUITING

St. Vincent Hospital - The Catholic University of Korea, Suwon

18014

WITHDRAWN

Hospital Virgen De Las Nieves De Granada, Granada

21100

WITHDRAWN

Ospedale di Circolo e Fondazione Macchi Varese, Varese

21565

RECRUITING

Gachon University Gil Medical Center, Incheon

23561

RECRUITING

Taipei Medical University - Shuang Ho Hospital, New Taipei City

25123

WITHDRAWN

Azienda Ospedaliera Spedali Civili di Brescia, Brescia

28031

WITHDRAWN

Hospital Universitario Infanta Leonor, Madrid

28034

RECRUITING

Hospital Universitario Ramon y Cajal, Madrid

28040

WITHDRAWN

Fundacion Jimenez Diaz University Hospital, Madrid

28100

WITHDRAWN

AOU Maggiore della Carita, Novara

28223

WITHDRAWN

Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón

31008

RECRUITING

Clinica Universidad de Navarra, Pamplona

RECRUITING

Clinica Universidad de Navarra, Pamplona

33081

WITHDRAWN

Centro Di Riferimento Oncologico (CRO), Aviano, National Cancer Institute, Aviano

33200

RECRUITING

VM Medical Park Mersin Hospital, Mezitli

33305

RECRUITING

Chang Gung Memorial Hospital - Linkou Branch, Taoyuan District

34418

RECRUITING

Istanbul University, Istanbul

35100

RECRUITING

Ege University, Izmir

40002

RECRUITING

Khon Kaen University, Khon Kaen

40705

RECRUITING

Taichung General Veterans Hospital, Taichung

41013

WITHDRAWN

Hospital Universitario Virgen del Rocio, Seville

42415

WITHDRAWN

Yeyungnam University Medical Center, Daegu

42601

RECRUITING

Keimyung University Dongsan Hospital, Daegu

44033

RECRUITING

Ulsan University Hospital, Ulsan

46009

COMPLETED

Instituto Valenciano de Oncologia, Valencia

46017

WITHDRAWN

University Hospital Doctor Peset, Valencia

47014

WITHDRAWN

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

47500

RECRUITING

Subang Jaya Medical Center, Subang Jaya

49201

RECRUITING

Dong-A University Hospital, Busan

49241

RECRUITING

Pusan National University Hospital, Busan

50008

RECRUITING

Show Chwan Memorial Hospital, Changhua

50200

RECRUITING

Chiang Mai University, Chiang Mai

50612

RECRUITING

Pusan National University Yangsan Hospital, Yangsan

54290

RECRUITING

Sakarya University Medical Faculty, Sakarya

54907

RECRUITING

Jeonbuk National University Hospital, Jeonju

55270

RECRUITING

Ondokuz Mayıs University, Samsun

59100

RECRUITING

University Malaya Medical Centre, Kuala Lumpur

RECRUITING

Tekirdag Namik Kemal University Hospital, Tekirdağ

67600

RECRUITING

Zonguldak Bulent Ecevit University, Zonguldak

68000

RECRUITING

Hospital Ampang, Kuala Lumpur

80100

RECRUITING

Hospital Sultanah Aminah Jhor Bahru, Johor Bahru

80756

RECRUITING

Kaohsiung Medical University Hospital, Kaohsiung City

83301

RECRUITING

Chang Gung Memorial Hospital Kaohsiung, Kaohsiung City

88586

RECRUITING

Hospital Queen Elizabeth, Kota Kinabalu

119074

RECRUITING

National University Hospital Singapore, Singapore

169608

RECRUITING

Singapore General Hospital, Singapore

400015

RECRUITING

Ion Chiricuta Oncology Institute, Cluj-Napoca

7650620

RECRUITING

Clinica Alemana de Santiago, Santiago

20231050

RECRUITING

Instituto Nacional de Cancer Jose Alencar Gomes da Silva, Rio de Janeiro

40050-410

RECRUITING

Hospital Santa Izabel - Santa Casa de Misericordia da Bahia, Salvador

40285-000

RECRUITING

Hospital Sao Rafael, Salvador

41950-640

RECRUITING

Ensino e Terapia de Inovacao Clinica Amo (Etica), Salvador

70200-730

RECRUITING

Hospital Sirio Libanes Brasilia, Brasília

85806-300

RECRUITING

Uopeccan Hospital do Cancer de Cascavel, Cascavel

81520-060

RECRUITING

Hospital Erasto Gaertner, Curitiba

90035-903

RECRUITING

Hospital de Clinicas de Porto Alegre, Porto Alegre

90110-270

RECRUITING

Centro Gaucho Integrado, Porto Alegre

17210-080

RECRUITING

Amaral Carvalho Hospital, Jaú

01308-050

RECRUITING

Hospital Sirio Libanes, São Paulo

01321000

RECRUITING

A Beneficencia Portuguesa de Sao Paulo, Oncology House, São Paulo

04501-000

RECRUITING

Instituto D'Or De Pesquisa e Ensino, São Paulo

08270-070

RECRUITING

Casa de Saude Santa Marcelina, São Paulo

1079NG

WITHDRAWN

Erasmus University Medical Center, Rotterdam

05505

RECRUITING

Asan Medical Center, Seoul

06591

RECRUITING

Seoul St Marys Hospital, Seoul

07345

RECRUITING

Yeouido St. Marys Hospital, Seoul

07120

COMPLETED

Hospital Universitari Son Espases, Palma

08221

WITHDRAWN

Hospital Universitari Mutua Terrassa, Terrassa

500-06

RECRUITING

Changhua Christian Hospital, Changhua

06620

RECRUITING

Ankara University Faculty of Medicine, Mamak

06100

RECRUITING

Gazi University, Ankara

RECRUITING

Sbu Dr.A.Y. Ankara Onkoloji Suam, Ankara

All Listed Sponsors
lead

Regeneron Pharmaceuticals

INDUSTRY