A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

PHASE3RecruitingINTERVENTIONAL
Enrollment

396

Participants

Timeline

Start Date

January 2, 2025

Primary Completion Date

June 8, 2027

Study Completion Date

August 1, 2028

Conditions
Crohn's Disease
Interventions
DRUG

Vedolizumab

Vedolizumab IV infusion.

DRUG

Upadacitinib

Upadacitinib over-encapsulated tablets.

DRUG

Placebo

Upadacitinib matched placebo capsules.

Trial Locations (138)

24

NOT_YET_RECRUITING

Adelaide, Meath and National Children's Hospital, Dublin

1000

NOT_YET_RECRUITING

University Clinical Centre - Ljubljana, Ljubljana

1020

NOT_YET_RECRUITING

Krankenhaus der Barmherzigen Brueder Wien, Vienna

1062

NOT_YET_RECRUITING

Central Hospital of Northern Pest - Military Hospital, Budapest

1070

NOT_YET_RECRUITING

Hopital Universitaire de Bruxelles/ Academisch Ziekenhuis Brussel, Brussels

1082

NOT_YET_RECRUITING

Semmelweis Egyetem, Budapest

1090

NOT_YET_RECRUITING

Medizinische Universitaet Wien - Allgemeines Krankenhaus der Stadt Wien (AKH) - Universitaetsklinik fuer Innere Medizin III, Vienna

1309

NOT_YET_RECRUITING

Vestre Viken HF - Baerum Sykehus, Drammen

1478

NOT_YET_RECRUITING

Akershus University Hospital, Lorenskog

2650

NOT_YET_RECRUITING

Hvidovre Hospital Medicinsk Gastroenterologisk Afdeling, Hvidovre

2820

ACTIVE_NOT_RECRUITING

Imelda GI Clinical Research Center, Bonheiden

3000

NOT_YET_RECRUITING

University Hospitals Leuven, Leuven

3010

NOT_YET_RECRUITING

University Hospital Bern (Inselspital), Bern

4000

NOT_YET_RECRUITING

Centre Hospitalier Chretien MontLegia, Liège

4021

NOT_YET_RECRUITING

Johannes Kepler Universitat Linz (JKU), Linz

4031

NOT_YET_RECRUITING

University Hospital Basel, Basel

5020

NOT_YET_RECRUITING

Landeskrankenhaus Salzburg, Innere Medizin I, Labor im Erdgeschoss, Salzburg

6020

NOT_YET_RECRUITING

Medical University Innsbruck, Innsbruck

6720

NOT_YET_RECRUITING

Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Szent-Gyorgyi Albert Klinikai Kozpont, I.Sz. Belogyaszati Klinika, Szeged

8048

NOT_YET_RECRUITING

Zentrum fur Gastroenterologie, Zurich

8091

NOT_YET_RECRUITING

Universitatsspital Zurich, Zurich

9000

NOT_YET_RECRUITING

Universitair Ziekenhuis Gent, Ghent

NOT_YET_RECRUITING

Aalborg Hospital, Aalborg

10000

NOT_YET_RECRUITING

University Hospital Centre Sestre Milosrdnice, Zagreb

10032

NOT_YET_RECRUITING

Columbia University Medical Center, New York-Presbyterian Hospital, New York

10075

ACTIVE_NOT_RECRUITING

Lenox Hill Hospital Northwell Health, New York

10122

NOT_YET_RECRUITING

AO Ordine Mauriziano di Torino, Torino

11490

NOT_YET_RECRUITING

National Defense Medical Center (NDMC) (Tri-Service General Hospital (TSGH)) - Neihu, Taipei

11528

NOT_YET_RECRUITING

University of Athens School of Medicine, Alexandra General Hospital, Athens

13015

NOT_YET_RECRUITING

Chu - Hopital Nord, Marseille

14163

NOT_YET_RECRUITING

Krankenhaus Waldfriede e.V., Berlin

15706

NOT_YET_RECRUITING

Complejo Hospitalario Universitario De Santiago De Compostela, Santiago de Compostela

16247

ACTIVE_NOT_RECRUITING

The Catholic University Of Korea, St. Vincent's Hospital, Suwon

20089

NOT_YET_RECRUITING

Humanitas Clinical And Research Institute, Rozzano

20132

NOT_YET_RECRUITING

Ospedale San Raffaele (HSR) Instituto Scientifico Universitario San Raffaele, Milan

24105

NOT_YET_RECRUITING

Universitaetsklinikum Schleswig-Holstein, UKSH-Campus Kiel, Kiel

28007

ACTIVE_NOT_RECRUITING

Hospital General Universitario Gregorio Maranon (HGUGM), Madrid

28046

ACTIVE_NOT_RECRUITING

Hospital Universitario La Paz, Madrid

29607

ACTIVE_NOT_RECRUITING

Gastroenterology Associates, Greenville

31000

NOT_YET_RECRUITING

Poliklinika Borzan d.o.o., Osijek

31008

ACTIVE_NOT_RECRUITING

Complejo Hospitalario de Navarra (CHN), Pamplona

31059

ACTIVE_NOT_RECRUITING

Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital Rangueil, Toulouse

32806

ACTIVE_NOT_RECRUITING

Orlando Health Ambulatory Care Center, Orlando

33305

NOT_YET_RECRUITING

Chang Gung Memorial Foundation Linkou Chang Gung Memorial Hospital, Taoyuan

33600

ACTIVE_NOT_RECRUITING

Centre Hospitalier Universitaire de Bordeaux - Hopital Haut-Leveque, Pessac

33612

ACTIVE_NOT_RECRUITING

USF Health Morsani Center for Advanced Healthcare, Tampa

34102

ACTIVE_NOT_RECRUITING

GI PROS, Inc., Naples

34943

ACTIVE_NOT_RECRUITING

The Catholic University of Korea, Daejeon St.Mary's Hospital, Daejeon

40201

NOT_YET_RECRUITING

Chung Shan Medical University Hospital, Taichung

40536

ACTIVE_NOT_RECRUITING

University of Kentucky, Lexington

40705

NOT_YET_RECRUITING

Taichung Veterans General Hospital, Taichung

42270

NOT_YET_RECRUITING

CHU St Etienne Hopital Nord, Saint-Etienne

42415

ACTIVE_NOT_RECRUITING

Yeungnam University Medical Center, Daegu

44093

ACTIVE_NOT_RECRUITING

Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hopital Hotel Dieu, Nantes

44281

NOT_YET_RECRUITING

Meir Medical Center, Kfar Saba

46026

NOT_YET_RECRUITING

Hospital Universitari I Politecnic La Fe, Valencia

46202

ACTIVE_NOT_RECRUITING

Indiana University (IU) Health University Hospital, Indianapolis

48108

RECRUITING

Inje University Haeundae Paik Hospital, Busan

49100

NOT_YET_RECRUITING

Rabin Medical Center - Beilinson Campus (Beilinson and Hasharon Hospital), Petah Tikva

50006

NOT_YET_RECRUITING

Changhua Christian Hospital, Changhua

51000

ACTIVE_NOT_RECRUITING

Clinical Hospital Center Rijeka, Rijeka

53226

NOT_YET_RECRUITING

Medical College of Wisconsin Cancer Center - Froedtert Hospital, Milwaukee

54511

NOT_YET_RECRUITING

Centre Hospitalier Regional Universitaire de Nancy, Hopital Brabois, Vandœuvre-lès-Nancy

57701

ACTIVE_NOT_RECRUITING

Rapid City Medical Center, Rapid City

59037

NOT_YET_RECRUITING

Hopital Huriez - CHRU de Lille, Lille

60431

NOT_YET_RECRUITING

Agaplesion Markus Krankenhaus, Frankfurt am Main

67065

NOT_YET_RECRUITING

St. Marien- und St. Annastiftskrankenhaus, Ludwigshafen

68167

NOT_YET_RECRUITING

Universitaetsklinikum Mannheim (Umm) - Ii Medizinische Klinik, Mannheim

70403

NOT_YET_RECRUITING

National Cheng Kung University Hospital, Tainan City

71013

NOT_YET_RECRUITING

Fondazione IRCSS Casa Sollievo Della Sofferenza, San Giovanni Rotondo

71110

NOT_YET_RECRUITING

University Hospital of Heraklion, Heraklion

75701

RECRUITING

Tyler Research Institute, LLC, Tyler

78229

RECRUITING

Southern Star Research Institute, LLC, San Antonio

80054

NOT_YET_RECRUITING

CHU d'Amiens-Picardie - Hopital SUD, Amiens

80131

NOT_YET_RECRUITING

Azienda Ospedaliero Universitaria Federico II di Napoli, Naples

80907

RECRUITING

Peak Gastroenterology Associates, Colorado Springs

90033

NOT_YET_RECRUITING

Keck Medicine Of USC - USC Healthcare Center 1, Los Angeles

92037

NOT_YET_RECRUITING

UCSD Medical Center, La Jolla

98101

ACTIVE_NOT_RECRUITING

Virginia Mason Medical Center, Seattle

98104

NOT_YET_RECRUITING

Swedish Cancer Institute, Seattle

98195

NOT_YET_RECRUITING

University of Washington Medical Center - Montlake, Seattle

3109601

NOT_YET_RECRUITING

Rambam Health Care Campus (RHCC), Haifa

6423906

NOT_YET_RECRUITING

The Tel Aviv Sourasky Medical Center, Tel Aviv

8410101

NOT_YET_RECRUITING

Soroka Medical Center, Beersheba

9080110

NOT_YET_RECRUITING

Pesquisare Saude, Santo André

17201130

NOT_YET_RECRUITING

Centro de Estudos Clinico do Interior Paulista - CECIP, Jaú

10029-5204

ACTIVE_NOT_RECRUITING

Mount Sinai Hospital - The Susan and Leonard Feinstein Inflammatory Bowel Disease (IBD) Clinical Center, New York

80050-350

NOT_YET_RECRUITING

Hospital Universitario Cajuru, Curitiba

18618-970

NOT_YET_RECRUITING

Faculdade de Medicina de Botucatu, Botucatu

21941-617

NOT_YET_RECRUITING

Universidade Federal do Rio de Janeiro (UFRJ)-Hospital Universitario Clementino Fraga Filho (HUCFF), Rio de Janeiro

05403-010

NOT_YET_RECRUITING

Hospital das Clinicas of the University of Sao Paulo (Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC/FMUSP)), São Paulo

1405-1243

NOT_YET_RECRUITING

Unidade de Pesquisa Clinica UPC Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo, São Paulo

T2N 4Z6

ACTIVE_NOT_RECRUITING

Heritage Medical Research Clinic - University Of Calgary, Calgary

R3A 1R9

NOT_YET_RECRUITING

University of Manitoba-Winnipeg Regional Health Authority-Health Sciences Centre, Winnipeg

B3H 2Y9

NOT_YET_RECRUITING

Dalhousie University, Halifax

L4M 7G1

RECRUITING

Barrie GI Associates, Barrie

L8S 4K1

ACTIVE_NOT_RECRUITING

McMaster University - Farncombe Family Digestive Health Research Institute (FFDHRI), Hamilton

L1J 0C7

RECRUITING

Taunton Surgical Centre-Oshawa Clinic, Oshawa

M6A 3B4

RECRUITING

Toronto Immune and Digestive Health Institute (TIDHI), Toronto

L4L 4Y7

NOT_YET_RECRUITING

Toronto Digestive Disease Associates, Vaughan

H2X 0A9

NOT_YET_RECRUITING

Centre Hospitalier de l'Universite de Montreal, Montreal

370 01

NOT_YET_RECRUITING

Nemocnice Ceske Budejovice, a.s., České Budějovice

500 05

NOT_YET_RECRUITING

Fakultni Nemocnice Hradec Kralove, Hradec Králové

500 12

NOT_YET_RECRUITING

Hepato-Gastroenterologie HK, s.r.o., Hradec Králové

190 00

NOT_YET_RECRUITING

IBD Clinical and Research centre, Prague

06108

NOT_YET_RECRUITING

Studiengesellschaft BSF, Halle

07747

NOT_YET_RECRUITING

Universitaetsklinikum Jena, Jena

185 37

NOT_YET_RECRUITING

Metaxa Cancer Hospital, Piraeus

D04 T6F4

NOT_YET_RECRUITING

University College Dublin (UCD) - St. Vincent's University Hospital (SVUH), Dublin

D09 V2N0

NOT_YET_RECRUITING

Beaumont Hospital, Dublin

00168

NOT_YET_RECRUITING

A. Gemelli University Hospital, Catholic University of the Sacred Heart, Roma

1105 AZ

NOT_YET_RECRUITING

Amsterdam UMC Research BV, Amsterdam

6525 GA

NOT_YET_RECRUITING

Radboud University Medical Center, Nijmegen

3015 GD

NOT_YET_RECRUITING

Erasmus Medisch Centrum, Rotterdam

5022 GC

NOT_YET_RECRUITING

Elisabeth TweeSteden Ziekenhuis (ETZ), Tilburg

N5021

NOT_YET_RECRUITING

Haukeland Universitetssjukehus (Haukeland University Hospital), Bergen

0424

NOT_YET_RECRUITING

Oslo Universitetssykehus HF, Ulleval, Oslo

90-153

NOT_YET_RECRUITING

Oddzial Kliniczny Gastroenterologii Ogolnej i Onkologicznej SPZOZ Uniwersytecki Szpital Kliniczny Nr 1 im. Barlickiego Uniwersytetu Medycznego w Lodzi, Lodz

60-354

NOT_YET_RECRUITING

Samodzielny Publiczny Szpital Kliniczny Im. H. Swiecickiego Um, Poznan

43-100

NOT_YET_RECRUITING

H-T. Centrum Medyczne Sp. z o.o. Sp.k., Tychy

02-507

NOT_YET_RECRUITING

Panstwowy Instytut Medyczny MSWiA, Warsaw

05-401

NOT_YET_RECRUITING

WIP Warsaw IBD Point Profesor Kierkus, Warsaw

3000-075

NOT_YET_RECRUITING

Unidade Local de Saude Coimbra, Coimbra

1349-019

NOT_YET_RECRUITING

Centro Hospitalar de Lisboa ocidental (CHLO), Hospital Egas Moniz, Lisbon

1649-028

NOT_YET_RECRUITING

Centro Hospitalar Universitario Lisboa Norte EPE, Lisbon

02447

RECRUITING

Kyung Hee University Hospital, Seoul

03722

ACTIVE_NOT_RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

06591

ACTIVE_NOT_RECRUITING

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

06973

ACTIVE_NOT_RECRUITING

Chung-Ang University Hospital, Seoul

07120

NOT_YET_RECRUITING

Hospital Universitari Son Espases, Palma

Unknown

NOT_YET_RECRUITING

Universitetssjukhuset i Linkoping, Endokrin- och magtarmmedicinska Kliniken (EM-Kliniken), Linköping

116 30

NOT_YET_RECRUITING

Ersta sjukhus, Stockholm

171 76

NOT_YET_RECRUITING

Karolinska Universitetssjukhuset - Hjartkliniken i Solna - Karolinska University Hospital, Stockholm

182 88

NOT_YET_RECRUITING

Danderyds Sjukhus AB, Stockholm

SE1 7EH

NOT_YET_RECRUITING

St Thomas' Hospital - Guy's & St Thomas' NHS Foundation Trust, London

E1 1BB

NOT_YET_RECRUITING

The Royal London Hospital - Barts Health NHS Trust, London

EH4 2XU

NOT_YET_RECRUITING

Western General Hospital, Edinburgh

G51 4TF

NOT_YET_RECRUITING

Queen Elizabeth University Hospital - NHS Greater Glasgow & Clyde - South Glasgow University Hospital Division, Glasgow

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