OCT Versus Angiography for Culprit Lesion Revascularization in Acute Myocardial Infarction PatiEnts

NARecruitingINTERVENTIONAL
Enrollment

1,500

Participants

Timeline

Start Date

March 25, 2024

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2029

Conditions
ST Elevation Myocardial InfarctionMyocardial Infarction
Interventions
PROCEDURE

Angiography-guided PCI group

The PCI procedure in this group will be performed as standard procedure. After deployment of stent, stent optimization will be done based on angiographic findings. The optimization guided by angiography should meet the criteria of angiographic residual diameter stenosis less than 10% by visual estimation and the absence of flow limiting dissection (≥Type C dissection). When angiographic under-expansion of the stent is suspected, adjunctive balloon dilatation will be strongly recommended.

PROCEDURE

Optical coherence tomography-guided PCI group

"\[Stent Optimization\]~1. Stent Expansion:~ Visually assess residual angiographic diameter stenosis \<10% AND~ ① In non-LM lesions: In-stent minimal lumen area (MSA) \>80% of the average reference lumen area OR \>4.5 mm2~ ② In LM lesion: MSA\>7 mm2 for distal LM and \>8 mm2 for proximal LM~2. Stent Apposition:~ No major malapposition (defined as a distance from stent strut to adjacent intima ≥400 um and \< 1mm length) of the stent over its entire length against the vessel wall~3. Edge Dissection:~No major edge dissection in the proximal or distal reference segments, defined as 5 mm from the edge of the stent, extended to media layer with potential to provoke flow disturbances (defined as \>60° of the circumference of the vessel at site of dissection and/or \>2 mm in length of dissection flap)"

Trial Locations (21)

11765

RECRUITING

Uijeongbu St Mary's Hospital, Uijeongbu-si

22711

RECRUITING

International St. Mary's Hospital, Incheon

41944

RECRUITING

Kyungpook National University Hospital, Daegu

42415

RECRUITING

Yeungnam University Medical Center, Daegu

42472

RECRUITING

Daegu Catholic University Medical Center, Daegu

44033

RECRUITING

Ulsan University Hospital, Ulsan

49241

RECRUITING

Dong-A University College of Medicine, Busan

49266

RECRUITING

Kosin University Gospel Hospital, Busan

52727

RECRUITING

Gyeongsang National University Hospital, Jinju

54538

RECRUITING

Wonkwang University Hospital, Iksan

54907

RECRUITING

Jeonbuk National University Hospital, Jeonju

57931

RECRUITING

St. Carollo Hospital, Suncheon

61469

RECRUITING

Chonnam National University, Gwangju

63241

RECRUITING

Jeju National University Hospital, Jeju City

02447

RECRUITING

Kyung Hee University Hospital, Seoul

03181

RECRUITING

Kangbuk Samsung Hospital, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

06973

RECRUITING

Chung-Ang University Hospital, Seoul

07804

RECRUITING

Ewha Womans University Seoul Hospital, Seoul

07985

RECRUITING

Ewha Womans University Mokdong Hospital, Seoul

08308

RECRUITING

Korea University Guro Hospital, Seoul

All Listed Sponsors
collaborator

Samsung Medical Center

OTHER

lead

Chonnam National University Hospital

OTHER