Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation

RecruitingOBSERVATIONAL
Enrollment

100

Participants

Timeline

Start Date

April 10, 2024

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Muscular Dystrophy, Facioscapulohumeral
Interventions
DIAGNOSTIC_TEST

Muscle ultrasound with surface electromyography and dynamometry

The three procedures are conducted simultaneously for upper and lower extremity muscles. A standard muscle ultrasound preset with a fixed depth of 4 cm or 6 cm will be used, depending on which muscle is visualized in accordance with our routine clinical protocols. During the dynamic approach, the transducer will be placed in a longitudinal fixed position on the muscle using a ProbeFix. All measured contractions in the different muscles will be recorded as short ultrasound videos.

DIAGNOSTIC_TEST

MRI scan

In Stage II, all patients and 10 healthy participants will undergo MRI. During the MRI procedure, we evaluate muscle fat fraction, muscle contractile volume, muscle inflammation and edema.

Trial Locations (1)

Unknown

RECRUITING

Radboud university medical center, Nijmegen

All Listed Sponsors
collaborator

Solve FSHD

UNKNOWN

lead

Radboud University Medical Center

OTHER