Immediate Pressor Response to Oral Salt

NARecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

July 7, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
High Blood Pressure
Interventions
OTHER

salt

After ≥8 hr overnight fasting, participants will be required to ingest 780 mg of sodium (2 g salt) and BP measured every 10 minutes for 2 hours to determine IPROS. For SSBP, Participants are put on low salt (50 mmol Na/day) followed by seven days of high salt diet (250 mmol Na/day). Participants' mean arterial pressure (MAP) difference between low- and high-salt diet will be used to define salt sensitivity (MAP≥8 mmHg) and salt resistance (MAP≤5 mmHg).

Trial Locations (2)

10101

NOT_YET_RECRUITING

Livingstone University Teaching Hospital, Livingstone

RECRUITING

Kanyama General Hospital, Lusaka

All Listed Sponsors
lead

Mulungushi University

OTHER