NCT06221553View on ClinicalTrials.gov

Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG

PHASE1RecruitingINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

March 1, 2024

Primary Completion Date

March 1, 2026

Study Completion Date

September 1, 2026

Conditions
DIPG Brain TumorDiffuse Intrinsic Pontine Glioma
Interventions
BIOLOGICAL

B7H3 specific CAR T cell with IL-7Ra signaling domain

Autologous T cells lentivirally transduced to express a B7H3 specific chimeric antigen receptor (CAR) with additional of IL-7 receptor alpha signalingdomain given via indwelling central nervous system (CNS) catheter

Trial Locations (1)

10330

RECRUITING

King Chulalongkorn Memorial Hospital, Bangkok

All Listed Sponsors
collaborator

King Chulalongkorn Memorial Hospital

OTHER

lead

Chulalongkorn University

OTHER